➥【第一劑mRNA新冠疫苗急性過敏者接種第二劑疫苗的安全性評估】:
■背景
文獻報告接種第一劑mRNA疫苗後出現急性過敏反應的機會約為2%,出現全身性嚴重過敏反應(anaphylaxis)的發生率則為萬分之2.5。第一劑出現急性過敏反應者,第二劑再接種同款mRNA疫苗的安全性如何,目前並不清楚。
■方法
共有包括麻省總醫院在內的5間醫院參與此多中心回溯性研究。研究分析於2021年1-3月間第一劑mRNA疫苗(Pfizer-BioNTech或Moderna)出現立即性過敏反應(immediate allergic reaction)者接種同款第二劑疫苗的安全性。納入分析的試驗參與者需符合:(1)第一劑施打後4小時出現症狀,(2)至少出現一種過敏症狀(註1),及(3)經由轉介,接受過敏/免疫諮詢評估者。
全身性嚴重過敏反應(anaphylaxis)的診斷則參照The Brighton Collaboration Anaphylaxis Working Group及NIAID/FAAN的定義(註2)。試驗參與者第一劑疫苗若出現嚴重的立即性過敏反應客觀徵候或有證據顯示為IgE所媒介的過敏反應(如:polyethylene glycol [PEG]皮膚測驗陽性或tryptase試驗陽性),則不建議施打第二劑mRNA疫苗(註3,註4)。
研究主要療效指標(primary endpoint)為第二劑疫苗的耐受性,定義為在第二劑施打後(1)未出現立即的症狀,或是(2)症狀輕微、自限性,或服用抗組織胺後即緩解。
■結果
共189位第一劑出現立即性過敏反應者納入分析,平均年齡43歲,86%為女性,69%第一劑接種Moderna,31%接種Pfizer-BioNTech。第一劑最常報告的反應是潮紅或紅斑(28%)、暈眩(26%)、麻刺感(24%)、咽喉發緊(22%)、蕁麻疹(21%)及喘鳴或呼吸短絀(21%)。
共22(17%)位符合anaphylaxis的標準。經評估後,159(84%)位接受了第二劑mRNA疫苗,其中47(30%)位在第二劑疫苗施打前使用抗組織胺。32 (20%)位在第二劑施打後出現了立即性過敏反應,但症狀均為輕微、自限性,或使用抗組織胺後即緩解。整體而言,所有接種者(包括19位第一劑疫苗發生anaphylaxis者)對第二劑疫苗都有良好的耐受性,平安完成兩劑疫苗療程。
■討論
此研究結果發現即使第一劑mRNA疫苗出現立即性過敏反應,再打同款第二劑疫苗僅20%出現過敏反應,且症狀都很輕微。基於此觀察,作者認為許多第一劑所出現的反應不一定是過敏反應,或是雖屬過敏反應,但並非是由IgE所媒介,且給予抗組織胺即可有效緩解。
因此,未來若須追加疫苗時,仍可再次施打mRNA疫苗。目前美國CDC針對第一劑mRNA疫苗出現立即性過敏反應者,建議第二劑可改打嬌生(Janssen)疫苗。不過此研究顯示即使第一劑出現立即性過敏反應,大部分人接種同款的第二劑疫苗仍是安全的,因此也許不需要考慮採用目前仍未知保護效果的多種混打策略。不過此研究的侷限性包括:回溯性研究、選樣偏差及參與醫院沒有共同的評估內容等,仍需謹慎應用研究結果...完整轉譯文章,詳連結:http://forum.nhri.org.tw/covid19/virus/j_translate/j2690 ( 財團法人國家衛生研究院 吳綺容醫師摘要整理)
▪註1.
過敏反應的症狀及徵候包括:蕁麻疹、嘴唇/眼/舌/喉嚨腫脹、咽喉發緊、嘴巴有金屬味、麻刺感、潮紅、紅斑、心跳加速、高血壓、喘鳴、呼吸短絀、噁心嘔吐、腹痛、暈眩、低血壓、低血氧、心跳變慢等。
▪註2.
NIAID/FAAN:美國國家過敏和傳染病研究所(National Instituteof Allergy and Infectious Diseases)/食品過敏反應和過敏性反應網絡(Food Allergy and Anaphylaxis Network)。
▪註3.
聚乙二醇(polyethylene glycol)為mRNA疫苗的賦形劑。
▪註4.
Tryptase儲存於肥大細胞(mast cell)顆粒中,肥大細胞活化時會將其釋放至血液中。因此tryptase濃度升高可作為全身性嚴重過敏反應(anaphylaxis)的實驗室指標。
📋 JAMA - 2021-07-26
Safety Evaluation of the Second Dose of Messenger RNA COVID-19 Vaccines in Patients With Immediate Reactions to the First Dose
■ Author:Matthew S. Krantz, Jason H. Kwah, Cosby A. Stone Jr, et al.
■ Link:https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2782348?resultClick=1
〈 國家衛生研究院-論壇 〉
➥ COVID-19學術資源-轉譯文章 - 2021/08/10
衛生福利部
疾病管制署 - 1922防疫達人
疾病管制署
同時也有3部Youtube影片,追蹤數超過83萬的網紅serpentza,也在其Youtube影片中提到,If you have a serious allergy, coming to China could be the last thing you ever do! No fear mongering or anything, but watch this video and be forewa...
「allergy reaction」的推薦目錄:
allergy reaction 在 CheckCheckCin Facebook 的最佳解答
【鼻敏感之苦】經常掛着兩行鼻涕的小朋友
⭐小朋友都不喜歡中藥材味道
⭐推拿刺激穴位增強小朋友體質
#星期三CheckCheckMail
小兒推拿紓緩鼻敏感
李太:「兒子自小就有鼻敏感,他很怕吃藥或喝中藥,有甚麼可以做呢?」
CheckCheckCin:中醫理論認為小朋友「臟腑嬌嫩,形氣未充」,即器官還未發育完善,尤其肺、脾、腎三個臟腑較為虛弱的話,就容易患上鼻敏感。天氣一轉小朋友的鼻敏感便容易發作,要避開致敏源,避免生冷及寒涼食物,亦可按揉迎香穴紓緩噴嚏及鼻水等症狀。平日父母可以替兒子進行穴位推拿,尤其適合0-6歲小兒,每日一次,五日為一個療程,不妨在睡前作為親子活動進行。
補脾經100下
位置:位於拇指的指紋面。
手法:操作者以拇指指腹順時針方向旋轉推動。
推肺經100下
位置:無名指末端指紋面。
手法:操作者以拇指指腹順時針方向旋轉推動。
推腎經100下
位置:小指末端指紋面。
手法:操作者以拇指指腹順時針方向旋轉推動。
敏感發作急救穴位:迎香穴
功效:驅風、通鼻竅及止涕,紓緩急性鼻敏感發作時的痕癢、鼻塞、鼻水及噴嚏。
位置:鼻翼外緣中點旁
方法:用陰力打圈按壓約1至2分鐘
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Chinese massage to relieve children’s nasal allergies
“My son has suffered from nasal allergies ever since you was young, and he’s afraid of eating Chinese medicines. What can I do?”
CheckCheckCin: According to Chinese Medicine theories, children’s internal organs are still tender and not completely developed. Those who have weak lungs, spleen, and kidneys may be prone to nasal allergies.
The moment the weather changes, these children would develop an allergic reaction, so remember to stay away from allergens and avoid eating raw and cold food.
On the other hand, you can massage the ‘Yin Xiang’ acupoint to relieve sneezing and a runny nose. Parents can also massage their children’s acupoints once a day for five days in a row, and it is especially helpful for children aged between 0 and 6. Consider giving your children a massage before sleep to strengthen family bonds.
The ‘bu pi jing’ spot 100 times
Location: tip of finger print of the thumb
Method: massage the spot in a clockwise circular motion with your thumb
The ‘tui fei jing’ spot 100 times
Location: tip of the finger print of the ring finger
Method: massage the spot in a clockwise circular motion with your thumb
The ‘tui shen jing’ spot 100 times
Location: the fingerprint of the little finger
Method: massage the spot in a clockwise circular motion with your thumb
First aid for allergy outbreak: Ying Xiang Point
Effects: expels wind, clears stuffed nose and stops runny nose. Relieves symptoms associated with nasal allergies such as itchy nose, stuffed and runny nose, sneezing.
Location: at the level of the midpoint of the lateral part of the nasal wing
Method: gently press on it and also rotate around in small circles for 1-2 minutes each time.
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#男 #女 #我狀態OK
allergy reaction 在 CheckCheckCin Facebook 的最佳解答
【鼻無可避?】三種體虛人士要小心
⭐據知每四個香港人便有一個患鼻敏感
⭐鼻敏感人士亦比較易患上其他敏感症
#星期二提升正能量
你容易患上鼻敏感嗎?
鼻敏感是天生的嗎?未必!中醫理論中鼻敏感稱為「鼻鼽」,主要因為肺氣虛虧、衛氣失固或寒邪所致的疾病,再加上天氣或外在環境轉變影響到臟腑運作而形成,有三種體質人士比較容易患上鼻敏感,如果你有以下症狀,要注意調理一下身體啊!
👃🏻肺氣虛
症狀:鼻癢、噴嚏、鼻塞、鼻涕清稀、反覆感冒、氣管敏感、怕風、多汗、容易疲倦
調理方法:溫補肺臟,適量食用補氣食物如淮山、薯仔、人參、紅棗、鵪鶉等。
補肺防風茶療
材料:北芪9克、防風9克、白朮6克、茯苓3克、蜂蜜適量
做法:材料洗淨放入鍋中,加入1000ml水,武火煮滾後調文火煮30分鐘,連藥材倒入保溫瓶,待茶變暖後加入蜂蜜即可。此茶可反覆沖泡至味淡。建議一星期飲用2-3次。
👃🏻脾氣虛
症狀:鼻癢、噴嚏、鼻塞較重、流稀白鼻涕,清晨與天氣潮濕時易發作;身體困倦、食慾欠佳、大便稀爛等。
調理方法:補益脾胃,適量食用健脾補氣食物如白米、薯仔、淮山、蓮子、薏米、白扁豆等。
✔️CheckCheckCin米水推介:朝米水
材料:紅米、薏米、白米
功效:去水腫、消胃脹、改善面黃
👃🏻腎氣虛
症狀:鼻癢、噴嚏、流清鼻涕,症狀在冬季或遇寒時較嚴重;怕冷、腰酸膝軟、耳鳴、夜尿多等。
調理方法:補益腎氣,適量食用補腎食物如黑芝麻、黑木耳、黑豆、烏雞、核桃、栗子等。
✔️CheckCheckCin米水推介:夕米水
材料:紅米、白米、黑芝麻、黑豆
功效:補救熬夜、烏髮養腎、紓緩腰痠
留言或按讚👍🏻支持一下我們吧!❤️ 歡迎 Follow 我們獲得更多養生資訊。
Are you prone to nasal allergies?
Are people born with nasal allergies? Not necessarily! According to Chinese Medicine theories, a nasal allergy is called ‘Bi Qiu’ in Mandarin, and it is caused by weakness of the qi in the lungs, weak immune system, or the cold pathogenic factor.
The changes of the weather and environment can also further affect the functions of the organs. Individuals of these three body constitutions might develop nasal allergies more easily, so if you have the symptoms below, do seek the treatment accordingly.
👃🏻Weakness of the qi in the lungs
Symptoms: itchy nose, sneezing, stuffy nose, clear mucus, frequently getting colds, aversion to wind, excessive sweating, fatigue
Health tip: warm and nourish the lungs; consume ingredients that can nourish the qi, such as Chinese yam, potato, ginseng, red date, and quail
Tea to nourish lung and protect against wind
Ingredients: 9g astragalus root, 6g root of fangfeng, 6g bighead atractylodes rhizome, 3g poria, honey to taste
Preparation: Rinse all ingredients thoroughly. Combine all ingredients with 1000ml of water and cook on high heat for 30 minutes. Pour all contents into a thermos. Add honey after the tea has warmed. Tea can be re-brewed until flavour weakens. For best results, drink for 2-3 days a week for a treatment.
👃🏻Weakness of the qi in the spleen
Symptoms: itchy nose, sneezing, stuffy nose, runny mucus but white in color; the allergic reaction might be triggered easily during the morning or when the weather is humid; fatigue, appetite loss, and loose stools
Health tip: nourish the spleen and the stomach; consume ingredients that can nourish the qi such as rice, potato, Chinese yam, lotus seed, coix seed, and white lentils
✔ CheckCheckCin Recommendation: Dawn Rice Water
Ingredients: Red Rice, Coix Seed, White Rice
Effects: Reduces water retention. Relieves abdominal bloating. Improves yellowish complexion.
Note: Not suitable for pregnant women.
👃🏻Weakness of the qi in the kidneys
Symptoms: itchy nose, sneezing, clear mucus; symptoms would become more severe during winter or the cold season; aversion to cold, soreness from lower back to knees, tinnitus, and nocturia (excessive urination at night)
Health tip: nourish the qi in the kidneys; consume ingredients that can nourish the kidneys such as black sesame, black fungus, black beans, black-boned chicken, walnut and chestnut
✔ CheckCheckCin Recommendation: Dusk rice water
Ingredients: Red Rice, White Rice, Black Sesame, Black Soya Bean
Effects: remedy to frequent late nights, improve hair quality and nourish kidneys, relieve sore lower back
Welcome to order through our website: www.checkcheckcin.com
Comment below or like 👍🏻 this post to support us. ❤️ Follow us for more healthy living tips.
#男 #女 #我疲憊 #我狀態OK #我畏冷 #氣虛 #痰濕 #感冒
allergy reaction 在 serpentza Youtube 的最讚貼文
If you have a serious allergy, coming to China could be the last thing you ever do!
No fear mongering or anything, but watch this video and be forewarned so that you can take precautions!
ADVCHINA: https://www.youtube.com/c/advchina
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DISCOUNT CODE: STAYAWESOME
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Join me on Facebook: http://www.facebook.com/winstoninchina
Twitter: @serpentza
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Music used: Virtual Vice - Killer in Kowloon

allergy reaction 在 KisaMake Youtube 的最佳解答
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allergy reaction 在 Chie Hidaka MUA Youtube 的最佳解答
Hello everyone!! Welcome back to my channel!!
Today I wanted to share wth you my first impression and review on "Alima Pure" products. The reason why I was gravitated towards "organic" or "natural" makeup products is that one of my client would constantly have this reaction whenever she puts eyeshadows. Her eye area would get swallen if she keeps wearing eye make up on. We didn't know and still don't know the certain cause of this reaction but we assumed some ingridients in eyeshadows are causing her allergy reation so I started to look for natural or organic make up products.
I say these eyeshadows could be a life saver if you have sensitive skin. It's kind of a hassle for me to apply these kind of powder formula eyeshadows compare to pressed ones but the pigmentation is good, easy to blend, nice color variation. Although, I highly suggest you to use primer before you apply them. They are easy to wear off. Other than that I'm pretty happy with the results considring they are natural products!!
http://alimapure.jp/
