The new sepsis consensus definitions: the good, the bad and the ugly
Recommendations
1.
Compare the old versus the new definitions using RCTs and epidemiological studies of sepsis and septic shock. The evaluation could demonstrate whether there is a need for the old definition of sepsis and whether SBP or MAP should be used.
2.
Evaluate the role of single or multiple biomarkers or genetic, epigenetic, inflammatory or anti-inflammatory factors to enhance the definition and/or provide important surrogate end-points to guide management decisions.
3.
Refine the SOFA score to define worsening organ dysfunction taking into account change from pre-existing organ dysfunction secondary to sepsis. Incorporate clinical parameters to define organ dysfunction for LMICs and thus expand the utility of the score globally.
4.
Determine diagnostic methodologies to differentiate infected from non-infected patients.
http://rdcu.be/mog
