Objective. Natural killer (NK) cell-deficient mice are useful models in biomedical research. NOD/SCID mice have been used as a model of this type in ...
NK cells generated in NOD/SCID mice are CD56 + CD3 -, express CD16 and NKp46, and are functional with respect to interferon-γ (IFN-γ) production in ...
由 H Harada 著作 · 2005 · 被引用 23 次 — NK cells are large granular lymphocytes that represent a critical component ... The NOD/SCID mice engrafted with human NK cells exhibited antitumor activity ...
The SCID mutation has been transferred onto a non-obese diabetic background. Animals homozygous for the SCID mutation have impaired T and B cell lymphocyte ...
In contrast, NOD/SCID/γc null (NOG) mice without common γ-chain inoculated with breast cancer cells were most efficient in the formation of a large tumor and ...
No NK cells were observed in spleen cells from NOD/SCID/γ c null mice and NOD/Shi-scid treated with anti-asialo GM1 antibody. B. Spleen cells from mice ...
Abstract 1070: Evaluation of human NK cell responses to PDX tumors in humanized NOD-scid IL2rg null (NSG) mice expressing human IL15.
#11.
Application of Highly Immunocompromised Mice for ... - MDPI
complement and impaired NK, macrophage, and dendritic cell functions [17]. The NOD/SCID mice were established by crossbreeding NOD and SCID ...
#12.
NSG mouse - Wikipedia
The NSG mouse (NOD scid gamma mouse) is a brand of immunodeficient laboratory mice, ... NSG branded mice lack mature T cells, B cells, and natural killer (NK) ...
#13.
Natural Killer Cells Generated from Cord Blood Hematopoietic ...
... NOD/SCID/IL2Rgnull mice. Using single photon emission computed tomography, we first demonstrated active migration of UCB-NK cells to ...
#14.
Differential growth patterns in SCID mice of patient-derived ...
cell antibody) and NOD-SCID mice (absent NK cell activity) to study the potential role of NK ... duration of the study.18 Treatment of Mouse NK cells have.
#15.
Human NK cell development in hIL-7 ... - Life Science Alliance
Cytokines serve as environmental factors that foster functional maturation of immune cells. Although NOD/SCID/IL2rgKO (NSG) humanized mice ...
#16.
Efficient Xenoengraftment in Severe Immunodeficient NOD ...
These results indicate that cell types other than splenic NK cells present in NOD-scid mice but not in NOG mice may be involved in this ...
#17.
Reevaluation of NOD/SCID Mice as NK Cell-Deficient ... - X-MOL
Objective. Natural killer (NK) cell-deficient mice are useful models in biomedical research. NOD/SCID mice have been used as a model of this ...
#18.
Two base pair deletion in IL2 receptor γ gene in NOD/SCID ...
Recently, humanized mice have been developed and used to replace primates. Immunodeficient mice deficient in T, B and natural killer (NK) cells ...
#19.
Higher susceptibility of NOD/LtSz-scid Il2rg-/- NSG mice to ...
NK cell cytotoxicity for lung cancer cells was markedly augmented by stimulation with IL-2. Compared with normal subjects, patients with lung ...
NOD scid Mice Developed to Reduce NK Cell Activity ... To overcome SCID limitations, the mice were crossed with a newly developed inbred strain, ...
#21.
Optimization of engraftment of human NK cells in NOD-SCID ...
Successful engraftment of human (hu) peripheral blood mononuclear cells (PBMCs) into mice with severe combined immune deficiency (SCID) would.
#22.
Lymphocyte phenotyping and NK cell activity analysis in ...
Although the presence of NK cell deficit is apparent in NOD/SCID mice, a certain level of remnant NK activity could be observed in these mice.
#23.
Immunodeficient Mouse Models: An Overview - Bentham Open
and B-cell development and absence of NK cells. Similar to NOD-scid IL2rnull. [1, 25, 26, 30]. HLA transgenic mice.
#24.
Impairment of NK Cell Function by NKG2D Modulation in NOD ...
Nonobese diabetic (NOD) mice, a model of insulin-dependent diabetes mellitus, have a defect in natural killer (NK) cell-mediated functions.
#25.
The Development of Next-generation PBMC Humanized Mice ...
Owing to the radiosensitivity of recipient NOD.scid mice (29) and the ... NK cells are largely deficient from the parental NSG/NRG/NOG humanized mouse ...
#26.
Cytometric and functional analyses of NK and NKT cell ...
The deficiencies in NK cell activity in NOD mice could only partly be ... of bone marrow cells recovered from NOD.scid recipients of.
#27.
Human Interleukin-15 Improves Engraftment of Human T Cells ...
NOD -SCID mice lack functional lymphoid cells and show little or no serum ... 37, 45), or elimination of mouse natural killer (NK) cells by ...
Natural killer cell receptor repertoires are diversified by a sto- ... day NOD-SCID mice received an intravenous co-infusion of pri- mary AML cells (12x106) ...
#29.
Reevaluation of NOD/SCID Mice as NK Cell-Deficient Models.
Abstract: Objective. Natural killer (NK) cell-deficient mice are useful models in biomedical research. NOD/SCID mice have been used as a model of this type ...
#30.
Radiosensitivity of immunodeficient mice in oncology studies
mouse (Shultz, 1995). The breeding of SCID mice into the NOD model impairs (but does not completely eliminate) NK-cell activity. These animals have been.
#31.
NOD-SCID mouse - Janvier Labs
On a NOD background, an gen- presen ng cells' (APC), myeloid cells' and the NK cell func ons are impaired. Most homozygotes do not have any detectable IgM, ...
#32.
Human NK cell development in hIL-7 and hIL-15 ... - ReadCube
Although NOD/SCID/IL2rgKO (NSG) humanized mice support investigation of human ... Although hIL-7 alone was not sufficient for supporting human NK cell ...
#33.
Humanized (SCID) Mice as a Model to Study human Leukemia
Since NOD/SCID mutated mice from the CB17-scid mice can allow ... Natural killer (NK)-cell activity, which is a main obstacle in the ...
#34.
Application of highly immunocompromised mice for ...
immunocompromised mice, especially, NK cell defective NOD strains such ... NOD/Scid mice with complete loss of NK cells were established by ...
#35.
Humanized mouse model supports development, function ...
In contrast to previous humanized mouse models, human NK cells in SRG-15 mice mediate efficient antibody-dependent cellular cytotoxicity and ...
#36.
Immunodeficient (B-NDG) Mice - Biocytogen
By deleting the IL2rg gene from the NOD-scid genetic background, the resulting B-NDG mice lack mature T cells, B cells, functional NK cells, ...
#37.
NOG mouse｜Humanized mouse｜Experimental Animals ...
With the development of the NOD/scid mouse, an improved SCID mouse, it was possible ... Lacking natural killer (NK) cells; Reduced dendritic cell function ...
#38.
Characterization of natural killer cells in ... - Fertility and Sterility
As expected, the NK cells from NOD/SCID mice display a detectable but lower cytotoxicity than BALB/c, as determined by standard 51Cr release ...
#39.
Humanized Mouse Models to Evaluate Cancer ...
tor) T cells and TCR (T cell receptor) T cells, NK (natural killer) cells, T ... innate immune system, SCID mice were crossed with nonobese diabetic (NOD) ...
#40.
Review Fate and functions of human adult lymphoid cells in ...
In particular, SCID and NOD/SCID mice received sublethal doses of total body irradiation and/or were injected with antibodies directed toward specific mouse. NK ...
#41.
BioLASCO_Immunodicient Mice
SCID mice show a severe combined immunodeficiency affecting both B and T lymphocytes. They have normal NK cells, macrophages, and granulocytes.
This mouse model lacks functioning T and B cells but do have functioning NK cells which limits engraftment. These mice are sensitive to irradiation and have ...
#43.
Humanizing NOD/SCID/IL-2Rγnull (NSG) mice using busulfan ...
Reconstitution of human cells in NSG mice transplanted with ... the NOD/SCID/IL-2Rγnull (NSG) mice, which lack T-, B-, and NK cell activity, ...
#44.
NK cell depletion and recovery in SCID mice treated with anti ...
The SCID C.B417 mice have high level of complement. The monoclonal antibody reactivity with mouse NK cells was tested cytometrically after IgG2a labeling with.
#45.
Comparison of biological features between severely immuno ...
Both strains of mice were generated by knock- out of Il2rg responsible for development of NK cells on the Nod-scid mouse lacking functional t and B lym-.
#46.
Initiation of immunotherapy with activated natural killer cells ...
We developed a model of neuroblastoma in immunodeficient NOD-scid gamma (NSG) mice in which human NB cells are injected beneath the capsule of the left kidney.
#47.
The CIEA NOG mouse - Taconic Biosciences
Defect of NK activities in spleen cells of NOG mice. The CIEA NOG mouse® lacks NK cell activity. NOG. C.B-17 scid. NOD scid. NOG. C.B-17 scid. NOD scid ...
#48.
NK cells do not mediate renal injury in murine adriamycin ...
NK cell depletion or reduction of NK function in NOD-SCID mice did not affect the severity of disease. In both wild type and immunodeficient models, ADR ...
#49.
Mice with Human Immune Systems: A Model for in Vivo Studies
NOD mice are known to have deficiencies in NK cells and myeloid cells. Researchers combined NOD and SCID mice, described by Greiner, ...
#50.
과학기술 지식인프라 ScienceON
Although the presence of NK cell deficit is apparent in NOD/SCID mice, a certain level of remnant NK activity could be observed in these mice.
#51.
The NSG™ Mouse - YouTube
#52.
NOD/SCID小鼠主要脏器重量、血生理生化指标和免疫细胞的测定
Conclusions The study indicates that NOD/SCID mice show the deficiency of T, B and NK cells function. The organ weights, blood physiological ...
#53.
Figure 5 - JCI
Myeloid-derived suppressor cells are implicated in regulating ... and cg KO NOD/SCID mice were subjected to NK cell quantification in tail ...
#54.
Human NK cell infusions prolong survival of metastatic human ...
The early repeated injection of IL2-activated NK cells in NB-bearing NOD/scid mice significantly increased the mean survival time, ...
#55.
Establishment of a rhabdomyosarcoma xenograft model in ...
T and B cells, and natural killer (NK) cells. Additionally, ... NK cell numbers in the NOD/LtSz-scid IL2rγnull-mice. The.
#56.
Comparing Immunodeficient Mice for Cancer, Immunity and ...
o Same as NOD scid mice o Additional Mutation: Il2rgtm1Wjl deficiency eliminates signaling from 6 interleukins and blocks NK cell ...
#57.
NOD/SCID/c null mouse - CiteSeerX
defective in NK cell activity as NOD/SCID/ c null mice. The same high engraftment rate of human mature cells was observed in ascites when peripheral blood ...
#58.
Development of Humanized Mouse Models for Biomedical ...
-complete absence of NK cells. •NOD-scid IL2rγnull mice engraft at high levels with human cells: 10-90% human cells in periphery.
#59.
CD34+ progenitor-derived NK cell and gemcitabine ...
Combining natural killer (NK) cell adoptive transfer with tumor-sensitizing ... therapy increases killing of ovarian cancer cells in NOD/SCID/IL2Rg null mice.
#60.
Effect of TLR3 and TLR7 activation in uterine NK cells from ...
NOD mouse cells behaved differently. In NOD mice ... T cells, rather than NK cells, in NOD mice. ... embryo loss in NOD/SCID mice that retained a remnant.
#61.
Cancer cells educate natural killer cells to a metastasis ...
129(Cg)-Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/J (ROSA mT/mG ), and NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice were obtained from the Jackson ...
#62.
Immune Dysregulation Gets the NOD - CORE
SCID (severe combined immunodeficiency) mice by T cells from spontaneously diabetic adult NOD diabetes. What are the factors, ... peripheral NK-like.
#63.
Targeted Cancer Immune Therapy - 第 217 頁 - Google 圖書結果
Other sources including FL cells and the sources mentioned below contain ... NK cell activity compared with C.B.-17-scid mice, with NOD/Ltz-scid mice ...
#64.
Immunobiology of Natural Killer Cell Receptors
One of the putative factors that make NOG mice more immunodeficient than NOD/ Shi-scid mice is the complete lack of natural killer (NK) cell activity.
#65.
Natural Killer Cells: At the Forefront of Modern Immunology
They noted that IL-2 activated NK cells killed the myeloma tumor in vitro and in vivo ... NK cells against metastatic neuroblastoma in NOD/scid mice [104].
#66.
Issues in Immunology Research: 2013 Edition
These results indicate that cell types other than splenic NK cells present in NOD-scid mice but not in NOG mice may be involved in this suppression.
#67.
Stem Cells and Disease - 第 204 頁 - Google 圖書結果
NOD / SCID - B2m 107 mitted cells that produce colonies of erythroid ... in the more NK - deficient NOD / SCID - B2 - microglobulin null mice reflects the ...
#68.
Immunology | ATCC
T-lymphocytes cancer cell. Natural killer cells. Natural killer (NK) cells were first identified for their ability to kill tumor cells ...
#69.
Regenerative Medicine - from Protocol to Patient: 2. Stem ...
As for mouse-intomouse repopulation assays, xenografts of human cells can be made quantitative through a limiting dilution approach, the term SCID ...
#70.
Regenerative Medicine: From Protocol to Patient
In the first approach, human cells within a fragment of hematopoietic tissue ... A reduced overall cellularity of the bone marrow in NOD/SCID mice may also ...
#71.
Proceedings of Light-Activated Tissue Regeneration and ...
However, PDT failed to inhibit tumor growth in T-cell-deficient NUDE mice. ... Depletion of natural killer (NK) cells in vivo with anti-asialo- GM1 antibody ...
#72.
Humanized Mice for HIV Research - 第 26 頁 - Google 圖書結果
... animal models such as NOG, NSG, and BRG mice [6–8]. These strains lack NK cells and produce better xenoengraftment results than do other strains, ...
#73.
Cytokines in the Genesis and Treatment of Cancer
Stimulatory Effects of IL-10 on NK Cells IL-10 is a potent stimulator of NK ... of αGalCer induces anergy and rescued NOD SCID mice from diabetes mellitus, ...
nod scid mice nk cells 在 The NSG™ Mouse - YouTube 的推薦與評價
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