【用藥知多D】藥物齊打交:葉酸 vs Methotrexate?
有時候,兩種藥可能會「打交」,總是難免會有一種「既生瑜,何生亮!(《三國演義.五十七回》)」的感慨。
不過凡事一體兩面,「打交」往往可能會「鷸蚌相爭,漁人得利」。
不用問,這個漁人當然是用藥者。
例如葉酸(Folic Acid)、Methotrexate(MTX)。
首先葉酸是其中一種維生素B,其中一項功能主要在讓細胞能夠如常進行細胞分裂。
至於Methotrexate則是一種抗代謝藥(Antimetabolite),主要在妨礙DNA的合成,一般主要影響一些細胞分裂速度較快的細胞,例如癌細胞、淋巴細胞(Lymphocytes)(T細胞(T-cells)、B細胞(B-cells))、表皮細胞(Epidermal Cells),適用於治療癌症、類風濕性關節炎(Rheumatoid Arthritis, RA)、銀屑病(Psoriasis)。
至於為什麼葉酸會跟Methotrexate「打交」呢?
哦,這是因為Methotrexate同時是一種葉酸拮抗劑(Folate Antagonist),主要透過抑制體內的二氫葉酸還原酶(Dihydrofolate Reductase, DHFR)將二氫葉酸(Dihydrofolate)轉化成為四氫葉酸(Tetrahydrofolate),便可能會妨礙葉酸在體內進行活化,從而可能會誘發葉酸缺乏症。
所以理論上,要是同時服用葉酸、Methotrexate,Methotrexate便可能會消耗體內的葉酸,誘發葉酸缺乏症,而葉酸卻可能會抗衡Methotrexate的藥效。
不過實際上,服用Methotrexate治療類風濕性關節炎、幼年型類風濕性關節炎(Juvenile Rheumatoid Arthritis)、銀屑病,同時服用葉酸不但未必會妨礙Methotrexate發揮藥效,反而可能會減少Methotrexate的副作用。[1][2][3][4]
其中葉酸可能有助預防Methotrexate所誘發的肝炎[5],因為肝炎往往足以逼使用藥者停藥,所以葉酸往往可能讓更多用藥者繼續服用Methotrexate治病。
所以要是用藥者正在服用Methotrexate,偶爾可能會跟葉酸同服,目的在減少Methotrexate的副作用。
(如欲了解更多用藥資訊,歡迎看看「小小藥罐子」網誌。)
💊💊💊💊💊💊💊
BLOG➡️http://pegashadraymak.blogspot.com/
IG➡️https://www.instagram.com/pegashadraymak/
YT➡️https://www.youtube.com/channel/UCQOMojMd6q7XnESMWwldPhQ
📕📕📕📕📕📕📕
著作➡️藥事知多D、用藥知多D、藥房事件簿、家居用藥攻略(各大書店有售)
Reference:
1. Hunt PG, Rose CD, McIlvain-Simpson G, et al. The effects of daily intake of folic acid on the efficacy of methotrexate therapy in children with juvenile rheumatoid arthritis. A controlled study. J Rheumatol. 1997;24:2230-2232.
2. Duhra P. Treatment of gastrointestinal symptoms associated with methotrexate therapy for psoriasis. J Am Acad Dermatol. 1993;28:466-469.
3. Ortiz Z, Shea B, Suarez-Almazor ME, et al. The efficacy of folic acid and folinic acid in reducing methotrexate gastrointestinal toxicity in rheumatoid arthritis. A meta-analysis of randomized controlled trials. J Rheumatol. 1998;25:36-43.
4. Hoekstra M, Van Ede AE, Haagsma CJ, et al. Factors associated with toxicity, final dose, and efficacy of methotrexate in patients with rheumatoid arthritis. Ann Rheum Dis. 2003;62:423-426.
5. van Ede AE, Laan RF, Rood MJ, et al. Effect of folic or folinic acid supplementation on the toxicity and efficacy of methotrexate in rheumatoid arthritis: a forty-eight week, multicenter, randomized, double-blind, placebo-controlled study. Arthritis Rheum. 2001;44:1515-1524.
同時也有5部Youtube影片,追蹤數超過9,480的網紅GreenBeautyKoKo,也在其Youtube影片中提到,Please come to visit my Facebook Page and web site ^.^. They are updated daily!! There a lot of different kinds of skincare tips and make up sharing!!...
「psoriasis treatment」的推薦目錄:
- 關於psoriasis treatment 在 Facebook 的最佳解答
- 關於psoriasis treatment 在 CheckCheckCin Facebook 的精選貼文
- 關於psoriasis treatment 在 Siennylovesdrawing Facebook 的最佳解答
- 關於psoriasis treatment 在 GreenBeautyKoKo Youtube 的精選貼文
- 關於psoriasis treatment 在 GreenBeautyKoKo Youtube 的最讚貼文
- 關於psoriasis treatment 在 GreenBeautyKoKo Youtube 的最佳貼文
- 關於psoriasis treatment 在 What is Psoriasis and the Best Psoriasis Treatment at Mayo ... 的評價
psoriasis treatment 在 CheckCheckCin Facebook 的精選貼文
【擺脫乾燥】拯救秋冬阿婆腳踭
⭐買鞋試鞋時好尷尬
⭐嚴重到出血的話實在一步一痛心
#星期二提升正能量
腳跟龜裂護理法
冬天天氣乾燥,大家都勤力塗抹潤膚乳,不過有一個位置不少人都會忽略——腳跟,突然有一日走路腳跟痛起來,才發現腳跟龜裂,有些裂口還會滲血。腳板底沒有皮脂腺,缺乏皮脂的滋潤保護,加上每天走路摩擦,都會令腳跟角質層變厚,經常穿鞋不穿襪、常穿高跟鞋的話更是高危人士。當表皮增厚而且乾燥,漸漸出現淺深不一的裂隙,中醫稱之為「手足皸裂」,裂口深達真皮就會令人感到痛楚甚至出血,如果本身有香港腳、乾癬、魚鱗癬等疾病,更容易出現腳跟龜裂的問題。
如果腳跟龜裂嚴重至出血程度要盡快就醫,輕度的話可以參考以下護理腳跟硬皮小貼士:
1) 如因常穿高跟鞋或鞋子不合腳,要將不合適的鞋子換掉;
2)睡前浸白醋足浴,有助軟化腳皮角質層;趁腳還濕潤時塗抹凡士林
3)不要撕去龜裂的外皮以免形成傷口;
4)家裡要養成穿拖鞋的習慣、
5)可用磨石將乾裂處的角質層輕力除去,再塗上潤膚乳
軟化腳皮足浴
材料:食用白醋3-4湯匙
做法:準備一盆約攝氏40度的暖水,水量浸過腳跟,加入食用白醋拌勻,浸泡雙腳15-20分鐘,最後以溫水清洗雙腳並擦乾、塗上潤膚乳即可。
留言或按讚👍🏻支持一下我們吧!❤️ 歡迎 Follow 我們獲得更多養生資訊。
Care tips for cracked heels
Everyone seems to apply moisturizing cream diligently to combat the dryness during winter, but there is one particular spot that most of us neglect – our heels.
We might be walking down the street one day, and feel a sudden pain on our cracked heels, which may have also started to bleed. This is because our foot soles do not have sebaceous glands to secrete sebum to moisten the skin. When we walk, the action of rubbing the skin against the shoes can create friction, causing the heels’ stratum corneum to thicken. This is particularly dangerous for individuals who always wear heels and those who do not wear socks.
When the thick stratum corneum becomes dry, cracks of varying degrees will develop. The cracks that have reached the inner part of the skin would hurt more deeply and might even bleed. Individuals with athlete's foot (tinea pedis), psoriasis and ichthyosis can develop heel cracks more easily.
If the condition becomes more severe, do seek proper medical treatment. But if the symptoms are mild, you may consider the following care tips:
1) Opt for heels or shoes that properly match the size of your feet
2)Enjoy a white vinegar foot bath before bed, as it can help soften the cuticle; apply a layer a Vaseline while your feet are still moist
3)Do not peel the outer layer when cracks have formed; you may inflict wounds on the fragile part
4)Develop the habit of wearing slippers at home
5)Gently rub the thickened skin with a pumice stone, then apply moisturizer
Foot bath that can help soften the cuticle on the heels
Ingredient: Edible white vinegar (3 – 4 tablespoons)
Method: Prepare a bowl of warm water (about 40 degree Celsius); dip the feet into the water and make sure the heels are submerged. Add in edible white vinegar and start stirring the water. Soak the feet for 15 – 20 minutes, and wash them with clean warm water. Dry the feet and apply moisturizer.
Comment below or like 👍🏻 this post to support us. ❤️ Follow us for more healthy living tips.
#男 #女 #我枯燥
psoriasis treatment 在 Siennylovesdrawing Facebook 的最佳解答
Herbbies : Apothecary Skincare from Mother Earth #HEAL #Facial/ #Body Oil & #Treatment Focus Oil consists of only #organic #herbs 🌿infused plant-based oil i.e. Mugwort, ❌ other harsh derivatives, chemicals or artificial content, 💯% #natural & made from quality herbs 🌿 Infused for at least 4️⃣weeks in its main oil carrier ~ grapeseed oil. It’s suitable for pregnant 🤰🏻 mums & kids 🧒🏻👧🏻 above 3️⃣years old, will try on #mylittleniece when she 👶🏻 reaches 3️⃣ years old then
Sienny Yong aka Siennylovesdrawing 👩🏻 has chosen for HEAL series ~ Repair, Hydrate & Protect as she is with dry skin & trust & wanna #experience the magical #beauty benefits of Mugwort:
🌿 Healing & nourishing properties
🌿 Anti-inflammatory properties
🌿 Soothe dry & irritated skin effectively - Its Vitamin E contains help to retain moisture & keep the skin supple & healthy
🌿 Its antioxidant contains protect skin from harmful UV rays 🔆 Yeah‼️Sunscreen
🌿 Its antibacterial contains kill bacteria & help treat skin breakouts - Stimulate skin to produce more collagen & reduce wrinkles on skin
🌿 Smoothen skin & feel more radiant
🌿 Specially for Eczema & Psoriasis with its antiseptic properties to keeping skin condition in controlled ☺️
Do check out her #userexperience #experience updates via her FB & IG (@siennylovesdrawing & @simplestraightforward) stories highlight album named #Herbbies. Twice daily ie. Morning 🔅🔆 after skin cleansing & after daily shower 🧖🏻♀️🚿in the late afternoon. Her skin has started to peel off in the 1️⃣st week of usage & her initial thought, "Hmm…🤔No skin improvement, in fact worsen & I got 28 years old from Zurich facequote app 📲 as compared to 27 years old on her 1️⃣st day of usage, OLDER for 1️⃣ year😭😭"
She 👩🏻 still continues her journey with trust & in 3️⃣rd & 4️⃣th weeks it seems like a skin renewal process. Her skin starts to slightly improve 🥰 & ❌ dehydrated looking. She applies the HEAL Treatment Focus Oil whenever necessary as #lipscare #lipstreatment & it improves dry lips 👄 , ❌ pain #lips breakage
She has read 📖 that Mugwort helps to relieve menstruation pain, I rubbed off with this HEAL range to ease the stomach discomfort ✌🏻😊
Guess what❓⁉️
She 👩🏻 has scored 10/10 Rate Your Look with #TikTok ( 🌐 tiktok.com/@siennylovesdraw) recently, HEAL series works for her #skin renewal
More of her beauty routines in her #blog via https://siennylovesdrawing.wordpress.com/ 👩🏻
#mugwort #herbbies #herbalskincare #herbalinfusedoil #skincaremalaysia #share #routine #sharing #sharingiscaring #blogging #blogger
psoriasis treatment 在 GreenBeautyKoKo Youtube 的精選貼文
Please come to visit my Facebook Page and web site ^.^. They are updated daily!! There a lot of different kinds of skincare tips and make up sharing!!
♥ check my web site
greenbeautykoko.com
♥ Like me on Facebook page
https://www.facebook.com/GreenBeautyKoKo
♥ Follow my blog
http://greenbeautykoko.blogspot.hk/
♥ Write email to me
[email protected]
Thank you for watching again!!
Green BeautyKoKo
xxoo

psoriasis treatment 在 GreenBeautyKoKo Youtube 的最讚貼文
Hi summer blossom,
May be some of you guys do not know what is the high frequency machine. But it is a safe facial machine for you to clean up your pores and acnes after extractions.
Here are those constraints: Pregnancy women, heart problem people, rosacea people or super sensitive people.
Check this video and see how to operate it:)
Please come to visit my Facebook Page and web site ^.^. They are updated daily!! There a lot of different kinds of skincare tips and make up sharing!!
♥ check my web site
www.greenbeautykoko.com
♥ Like me on Facebook page
https://www.facebook.com/beautykoko
♥ Follow my blog
http://greenbeautykoko.blogspot.hk/
♥ Write email to me
[email protected]
Thank you for watching again!!
BeautyK♥K♥

psoriasis treatment 在 GreenBeautyKoKo Youtube 的最佳貼文
Halo everyone,
Yogurt is really good for health. Babies love to eat yogurt too. Today I showed you guys how to make your own yogurt by yourself. It is very easy and cost saving.
What you need: Easiyo yogurt powder, Easiyo makers and water.
Please come to visit my Facebook Page and web site ^.^. They are updated daily!! There a lot of different kinds of skincare tips and make up sharing!!
♥ check my web site
www.greenbeautykoko.com
♥ Like me on Facebook page
https://www.facebook.com/beautykoko
♥ Follow my blog
http://greenbeautykoko.blogspot.hk/
Thank you for watching again!!
BeautyK♥K♥
xxoo

psoriasis treatment 在 What is Psoriasis and the Best Psoriasis Treatment at Mayo ... 的推薦與評價
In this video, Dr. Alina Bridges tells us that psoriasis is a long-term skin condition in which red scaly patches areas appear on any part ... ... <看更多>