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#1. Progression-Free Survival and Time to Progression as Real ...
Background: Progression-free survival (PFS) and time to progression (TTP) have been reported to correlate with overall survival (OS) in several cancer types. To ...
#2. Progression-free survival and time to ... - Annals of Oncology
Of note, only one trial used both PFS and TTP as efficacy end points; for this trial, the definition of TTP differed from that of PFS in considering only deaths ...
#3. Progression-free survival - Wikipedia
Progression -free survival (PFS) is "the length of time during and after the treatment of a disease, such as cancer, that a patient lives with the disease ...
#4. original articles breast cancer Progression-free survival and ...
Progression -free survival (PFS) is defined as the time elapsed between treatment initiation and tumor progression or death from any cause, with censoring of ...
#5. Definition of progression-free survival - NCI Dictionary of ...
The length of time during and after the treatment of a disease, such as cancer, that a patient lives with the disease but it does not get worse. In a clinical ...
#6. Literature-based analysis of 36 randomized trials. - ASCO ...
Progression -free survival and time to progression as surrogate markers of overall survival in patients with advanced gastric cancer: ...
#7. 美國FDA於2018年12月發表「用於核准抗癌藥品及生物製劑的 ...
D. 無惡化存活期(Progression-free survival，PFS)和腫瘤惡化. 時間(Time to progression，TTP)：TTP 為從隨機分配至客. 觀發生腫瘤惡化(不含死亡)的期間，而PFS 為從 ...
#8. Detecting an Overall Survival Benefit that Is Derived From ...
Whether progression-free survival (PFS) or overall survival (OS) is the more ... The continuation strategy at the time of progression is not ...
#9. Comparison of Duration of Response vs Conventional ...
Restricted Mean Time of Progression-Free Survival Partitioned Into ... vs Conventional Response Rates and Progression-Free Survival as ...
#10. Clinical Trial Endpoints for the Approval of Cancer Drugs and ...
Disease-Free Survival (and Event-Free Survival) . ... Time to Progression and Progression-Free Survival .
#11. A Meta-Analysis of 37 Trials - Clinical Breast Cancer
We analyzed whether progression-free survival (PFS) and time to progression (TTP) can be used as surrogate end points to study the effect of the treatment ...
#12. Progression-free survival at 24 months and subsequent ...
Patients who were progression-free within 24 months after initial treatment resulted in favorable long-term outcomes, with OS times not ...
#13. Predicting Progression-Free Survival Using MRI-Based ...
Predicting Progression-Free Survival Using MRI-Based Radiomics for Patients ... The real-time polymerase chain reaction (PCR) analysis was ...
#14. Relationship between Progression-free Survival and Overall ...
In some ways, PFS is an outcome with some limitations, as it can only be measured at the time of a scheduled imaging scan or other assessment (e.g. leading to ...
#15. On-line Supplemental Appendix Protocol Definitions ...
Progression -free survival (PFS) was measured from the date of randomization ... Time to progression (TTP) was calculated as the time (days) from the date of.
#16. Progression-Free Survival: What Does It Mean for ...
Progression -free survival (PFS), defined as the time from random assignment in a clinical trial to disease progression or death from any cause, has recently ...
#17. What do clinical trial results mean? | Cancer Research UK
Progression free survival (PFS), The time between treatment aimed at shrinking or controlling cancer, and signs that it has started to grow ...
#18. Appendix 1 to the guideline on the evaluation of anticancer ...
Methodological consideration for using progression-free survival (PFS) or ... Generally, the exact time of progression will not be known.
#19. Progression-free survival and time to progression as primary ...
It is common in oncology trials to use progression-free survival (PFS) as a primary endpoint: this outcome is defined as the time elapsed from ...
#20. Progression-free survival at 2 years is a reliable surrogate ...
The median follow-up time for censored patients was 57 months. The ORR was 72%, median PFS was 12 months, and median survival time was 39 months ...
#21. Progression-Free-Survival (PFS) Analysis in Solid Tumor ...
Progression -free survival (PFS) is commonly used as a primary endpoint in Phase III of solid tumor oncology clinical studies. PFS is defined as the time ...
#22. Progression Free Survival - JMP
Progression free survival is used to describe how long patients can go without the disease without getting worse. This process uses a modified survival plot ...
#23. 癌症臨床試驗的常用終點 - 呼吸希望
疾病無惡化存活期(Progression-free survival, PFS)：這是指從治療開始直至檢測 ... 疾病惡化時間(Time to progression, TTP)：這是指從隨機試驗開始直至客觀腫瘤惡化 ...
#24. Clinical Significance of the Relationship between Progression ...
Progression -free survival (PFS) and OS are two common endpoints in cancer trials. ... ≤74 years of age at the time of chemotherapy; Eastern Cooperative ...
#25. Prediction of survival benefits from progression ... - BMJ Open
Objectives To investigate whether progression-free survival (PFS) can be ... PFS was defined as the time from random assignment to disease progression (as ...
#26. Surrogacy of Time to Progression for Overall Survival in ...
Time to progression (TTP) is widely used as the endpoint in early-phase trials of advanced hepatocellular carcinoma (HCC).
#27. A Proposal for Progression-Free Survival Assessment in ...
Overall survival, which is defined as the time from randomization to death by any cause, is used as a true endpoint in oncology clinical trials. In nearly a ...
#28. Bias in progression‐free survival analysis due to intermittent ...
The time to the composite progression-free survival endpoint is then subject to a hybrid censoring scheme involving interval censoring for ...
#29. PFS-OS - NICE Decision Support Unit
Progression -free survival (PFS), time-to-progression (TTP) and overall survival (OS) are commonly used endpoints in randomised controlled trials (RCTs) and ...
#30. What Progression-Free Survival Means After Cancer
A longer progression-free survival period shows a longer period of stability. Studies may continue for several years and show the progression- ...
#31. Progression-Free Survival After Six Years (Median) Follow-Up ...
The first clinical trial of rituximab (Rituxan) in combination with CHOP chemotherapy (cyclophosphamide [Cytoxan, Neosar], doxorubicin HCl, ...
#32. Sorafenib in Advanced Hepatocellular Carcinoma | NEJM
Conclusions. In patients with advanced hepatocellular carcinoma, median survival and the time to radiologic progression were nearly 3 months ...
#33. Progression-free survival (PFS) | Cancer.Net
The length of time during and after treatment that the cancer does not grow or spread further. This term is often used in the context of scientific ...
#34. Estimating progression-free survival in patients with ...
In this pilot study we assess whether we can estimate disease progression and progression free survival (PFS) from routinely collected ...
#35. Assessment of progression-free survival as a surrogate end ...
A Weibull parametric model to failure time data was fit to determine whether longer PFS was significantly and meaningfully predictive of longer ...
#36. Progression-free survival as a surrogate endpoint for overall ...
Background:Progression-free survival (PFS) has been adopted as the primary endpoint in many randomized controlled trials, ...
#37. Community-driven development of a modified progression ...
In addition, surrogate endpoints such as objective response rate, time to progression (TTP), progression-free survival (PFS) as well as symptom control ...
#38. Progression-free survival, patient-reported outcomes, and the ...
Progression -free survival (PFS) is an endpoint not so confounded, and one that requires fewer patients and less time to arrive at a conclusion about a new ...
#39. Progression-free survival in the ICON8 trial - The Lancet
This narrow time-window is precise and highly informative; however, the corresponding median progression-free survival time was 20·8 months ...
#40. Chronological Trends in Progression-Free, Overall, and Post ...
To investigate this issue, we analyzed chronological trends in PFS and OS in advanced NSCLC using restricted mean survival times (RMSTs).
#41. Prolonged Progression Free Survival and Time to Next ...
Prolonged Progression Free Survival and Time to Next Treatment Are Achievable Outcomes in Patients with Systemic AL Amyloidosis Treated with Novel Agent ...
#42. Tyrosine Kinase Inhibitor Prolongs Progression-Free Survival
The first randomised study in malignant pheochromocytoma and paraganglioma (MPP) has found that sunitinib prolongs progression-free survival ...
#43. A Meta-Analysis of 37 Trials.,Clinical Breast Cancer - X-MOL
Background Progression-free survival (PFS) and time to progression (TTP) have been reported to correlate with overall survival (OS) in several cancer types.
#44. PACIFIC: Progression-Free Survival Increase in NSCLC
PACIFIC: Progression-Free Survival Increase in NSCLC ... who had stable disease, it did help improve the time to progression as well.
#45. Extrapolation from Progression-Free Survival to Overall ...
Trials of drugs for cancer treatment may cause a reduction in tumour size for a period of time but might not extend life, or do so by a very small amount.
#46. Pembrolizumab Improves Progression-Free Survival vs ...
Pembrolizumab Improves Progression-Free Survival vs Chemotherapy in First-Line Treatment of Microsatellite Instability–High Advanced Colorectal ...
#47. Progression Free Survival or Overall Survival? Reconciling an ...
OS measures the amount of time between receiving a therapy and succumbing to an illness. Essentially the best medicines for patients may well be ...
#48. Immunotherapy doubles progression-free survival time of ...
'Progression-free survival' is the length of time during and after the treatment of a disease, such as cancer, that a patient lives with the ...
#49. AstraZeneca presents superior progression-free survival for ...
* Time from randomisation to the first documented tumour progression, or death in the absence of progression. Randomisation in the PACIFIC trial ...
#50. Understanding the endpoints in oncology: overall survival ...
Understanding the endpoints in oncology: overall survival, progression free survival, hazard ratio, censored value ; The time from the ...
#51. Factors Associated With Progression-free Survival, Overall ...
Pharmacy Times interviewed Adam Olszewski, MD, associate professor of medicine in Alpert Medical School at Brown University, to discuss his ...
#52. Correlation of Survival and Progression-free Survival ...
Survival analysis involves statistical assessment time to death or time to relapse. Clinical trials in cancer commonly have survival as an endpoint, ...
#53. Approaches Used to Model the Relationship Between ...
Approaches Used to Model the Relationship Between Progression-Free Survival (PFS) / Time-To-Progression (TTP) And Overall Survival (OS) Within ...
#54. Complete response correlates with long-term survival and ...
... and overall survival or progression-free survival after HDT/SCT, ... (time to disease progression [TTP], progression-free survival [PFS] ...
#55. Understanding Overall Survival in Metastatic Breast Cancer
Progression -Free Survival. This is the amount of time cancer doesn't grow or spread while on treatment. It's about putting cancer growth on pause. OTHER ...
#56. Trait: progression free survival - GWAS Catalog - EMBL-EBI
Progression free survival is a measurement from a defined time point e.g. diagnosis and indicates that the disease did not progress i.e. ...
#57. A Review of Statistical Issues with Progression-Free Survival ...
Suppose the median PFS time is 24 months versus 40 months, respectively, in the two treatment ...
#58. Progression-Free Survival (PFS) | REVLIMID® (lenalidomide ...
The primary endpoint for the randomized study was progression-free survival, defined as the time from date of randomization to first documentation of disease ...
#59. Seeking Ways to Extend Progression-Free Survival ... - OncLive
Patients are likely to relapse and become refractory to treatment over time, and physicians seek new treatment options. 3,4. One of the options ...
#60. Progression-free Survival After MWA Plus Durvalumab and ...
The study is exploratory and cannot be statistically powered for comparisons. Median progression-free survival (PFS) time is chosen as the ...
#61. Ann_Thorac_Med_2015_10_1_...
therapies in patients with small cell lung cancer (SCLC). We examined whether progression-free survival (PFS), post-progression survival (PPS), ...
#62. Measuring patient outcomes in clinical trials - Roche
Progression -free survival. PFS measures how long a person lives without the disease worsening beyond a certain extent. We can assess PFS in terms of tumour ...
#63. OS vs. PFS: What You Need to Know - Metastatic Trial Talk
In some trials, researchers set out to look at progression-free survival (PFS), a measure of how long someone is on a treatment before their ...
#64. Meta-analysis of the validity of progression-free survival as a ...
BACKGROUND: The validity of progression-free survival (PFS) as a surrogate endpoint for overall survival (OS) in metastatic colorectal cancer (mCRC) trials ...
#65. Define the term Progression Free Survival - YouTube
What that is a measurement of is the time interval from the time of treatment to the time that the tumor comes back. So it's an important ...
#66. Understanding the effect of treatment on progression-free and ...
os Overall survival T02 ∧ T12, subject to right censoring at C. ttp Time to progression T01, often imputed to time of detection,.
#67. Apatinib therapy improves progression-free survival in iodine ...
Apatinib therapy in patients with radioactive iodine-refractory thyroid cancer is safe and able to improve progression-free survival.
#68. Copanlisib + Rituximab Shows Superior efficacy in Marginal ...
http://journals.lww.com/oncology-times ... 10 HEMONC TIMES ... in progression-free survival for patients treated with copanlisib plus.
#69. Cantargia advances nadunolimab against pancreatic cancer ...
The primary endpoint for the trial is overall survival. ... progression-free survival (iPFS) and overall survival are longer than expected ...
#70. List of drugs in phase 3 clinical trials 2021
Progression -free survival is the amount of time before cancer grows or spreads to Phase 3: A phase of research to describe clinical trials that gather more ...
#71. Reduced Radiation in Oropharynx Cancer - Medscape
Comparable progression-free survival was observed in intermediate-risk patients with HPV and oropharynx cancer who received less intense ...
#72. Overall Survival Results of PEACE-1 a Phase 3 Trial in Men ...
... in the trial years ago, ADT alone was the standard of care at this time. ... really related to the progression-free survival outcome.
#73. Second-Line Enhertu May Be 'Standard of Care' for Patients ...
The median progression-free survival was not evaluable with Enhertu ... duration of response (the time a tumor responds to treatment without ...
#74. Elacestrant Shines in EMERALD Trial - Clinical Oncology News
... significant and clinically meaningful improvement in progression-free survival versus standard-of-care endocrine therapy in...
#75. 癌症病人預後的評估工具簡介：存活期、反應率 - 健康跟著走
relapse free survival 定義- 無病存活率（disease-freesurvival,DFS）是指病人診斷癌症 ... overall survival, progression free survival and time to progression, ...
#76. First-Line Axi-Cel Appears Effective in High-Risk Large B-Cell ...
The median time to initial response was 1 month. At the data cutoff, ... The estimated 12-month progression-free survival was 75%.
#77. Backed by Strong Survival, Janssen Submits BLA for Multiple ...
In patients who responded, median time to first confirmed response was 1.2 ... Progression-free survival (PFS) rate at nine months was 59%.
#78. Valemetostat New Drug Application Submitted in Japan for ...
... time to response, duration of response, progression-free survival, overall survival and safety. A total of 25 patients were enrolled in ...
#79. Ayala Pharmaceuticals Announces Key Business Objectives for
... progression free survival, and relapse free survival. ... the timing of and plans to initiate additional clinical trials of AL101 and ...
#80. HER2CLIMB final OS analysis confirms tucatinib HER2 ...
... showed significantly improved OS and progression-free survival (PFS) with the use of tucatinib rather than placebo alongside trastuzumab ...
#81. Ayala Pharmaceuticals Announces Key Business Objectives ...
... progression free survival, and relapse free survival. ... the timing of and plans to initiate additional clinical trials of AL101 and ...
#82. High-Fiber Diet May Benefit Melanoma Patients on ...
Higher intake of dietary fiber linked to longer progression-free survival in melanoma patients on immune checkpoint blockade.
#83. High-dose radiation thwarts tumor growth in patients with ...
ARLINGTON, Va. - High-dose radiation therapy can be used to lengthen progression-free survival for people with advanced lung cancer when ...
#84. Is Second-Line Axi-Cel the New Standard in Aggressive B ...
I mean, less than 20% of those patients had meaningful progression-free survival, whereas the investigation arm, the CAR-T cell arm, ...
#85. FDA Grants Breakthrough Therapy Designation for Cullinan ...
... progression free survival in heavily pre-treated patients. ... the following: uncertainty regarding the timing and results of regulatory ...
#86. Japan approves Keytruda plus Lenvima combination for ...
The MHLW approval marks the first time for Keytruda plus Lenvima ... survival and progression-free survival compared to chemotherapy.”.
#87. prostate cancer - MDLinx
Metastasis-free survival did not differ when enzalutamide and abiraterone ... 0·33–0·47), and progression-free-survival (0·44, 0·36–0·54), ...
#88. Research: High-fiber diet associated with improved response ...
... with sufficient fibre intake had improved progression-free survival ... with a 30 per cent lower risk of cancer progression or death.
#89. Genprex Expands Gene Therapy Oncology Pipeline to Include ...
... with a median progression free survival of 5.2 months. ... that it files from time to time with the Securities and Exchange Commission ...
#90. BRCA 1/2 Germline Mutation Predicts the Treatment ... - MDPI
... BRCA 1/2 mutation showed longer progression-free survival than those without a BRCA 1/2 mutation, without a significant time difference (18 months vs.
#91. Tissue-Specific Therapeutics (TSTx) Targeting Oncology ...
... progression-free survival (PFS) of 4 months with zero drug-related severe adverse events and zero dose interruptions due to toxicity.
#92. Study Identifies Early Risk Factors for Kidney Failure in AAV
... patients at greater risk of progression to kidney failure so they can ... overall survival, dialysis-free survival, and AAV relapse and ...
#93. Phase 1 Study in R/R Hodgkin Lymphoma Shows Significant ...
Median follow-up time in 28 surviving patients was 28 months (range, 1-41). Patients had 1-year progression-free survival (PFS) of 52% and ...
#94. High-fiber diet improves response to immunotherapy in ...
The 37 patients with sufficient fibre intake had improved progression-free survival (median not reached) compared to the 91 patients with ...
#95. Colon cancer - Symptoms and causes - Mayo Clinic
Over time some of these polyps can become colon cancers. ... Sign up for free and receive the latest on colon cancer treatment, care and ...
#96. Paper: Pembrolizumab Plus Vorinostat Induces Responses in ...
The median follow-up time in 28 surviving pts was 18 months (mo, range 1-41). The median duration of response, progression-free survival ...
time to progression and progression-free survival 在 Define the term Progression Free Survival - YouTube 的推薦與評價
What that is a measurement of is the time interval from the time of treatment to the time that the tumor comes back. So it's an important ... ... <看更多>