關於 toll receptor ，我們在網路上蒐集到這些相關的討論、資訊與評價

➥ 臨床發現年輕無慢性病史的男性染病後可能成為新冠肺炎重症病患，原發性免疫功能不全為可能造成其重症的原因之一，Hoischen博士和其研究團隊針對四位無慢性病史的新冠肺炎重症年輕男性病患進行全外顯子定序(whole-exome sequencing)。


結果發現這四位無慢性病史的新冠肺炎重症年輕男性病患均帶有toll-like receptor 7 (TLR7) 基因功能缺失(loss-of-function)的基因變異，研究結果指出個案感染新冠肺炎後可能因自身帶有TLR7基因變異，而導致TLR7基因的功能缺失，造成干擾素第一型和第二型免疫功能不全，有一定程度的關聯。


初步研究結果可作為感染新冠肺炎後病理機制之參考。( 財團法人國家衛生研究院 蔡慧如博士摘要整理，完整文章，詳：http://forum.nhri.org.tw/covid19/virus/j_translate/j1913/)


📋 JAMA - 2020-07-24
Presence of Genetic Variants Among Young Men With Severe COVID-19
■ Author：Caspar I. van der Made CI, Simons A, Schuurs-Hoeijmakers J, et al.
■ Linkhttps://jamanetwork.com/journals/jama/fullarticle/2768926


〈 國家衛生研究院-論壇 〉
➥ COVID-19學術資源-轉譯文章 - 2020/08/26
衛生福利部
疾病管制署 - 1922防疫達人
疾病管制署

#bj4

Core microbiota

Cosmetics influence skin microbiota

Gut brain axis

The gut is the first brain?

Gut and testosterone

Microbiota and metabolite

Short chain fatty acids affect mitochondrial bioenergetics

We believe that microbiota control mitochondria and control the harmony of the organ

The bacteria in the soil communicate with the bacteria in the gut and the historical remnants of bacteria of determine our viability as a human through a system of transfer of knowledge.

MicroRNA/epigenome/holobiont

Holobiont /superorganism/ecology

Toll-like receptor/immune response

Low level of expression TLR/overactive immune system

Glyphosate/oral tolerance/immune response

Europeans that have no reaction to gluten in Europe and they come to US and they have to go in gluten-free when they get sick.
Pesticides? Glyphosate protein?

Tolerance/digestion(break down of food)/lack of enzymes/

Immune system react to protein not amino acid

Vitamin A deficiency/vitamin D/glutathione/opiods(exercise,emotion)/regulatory T-cell/all impact this tolerance systems

Superorganism /educate the immune system in the gut how to live in harmony

We have to get sick in order to fit immune system

Retrovirus

Butyrate/intestinal gut barrier

Microbiota/ROS production/food/energy balance

DNA microRNA epigenetic mitochondrial microbiota axis

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Sayer Ji
Dr Davis kharrazian
Kiran krishnan
Dr Ted achacosa
以上幾位真的太強大了！

還剩6小時free

中央研究院基因體研究中心謝世良特聘研究員團隊進一步研究CLEC5A在對抗細菌感染時的角色，發現此基因是比「類鐸受體(Toll-like receptor 2- TLR2)」更關鍵的防衛因子，未來可望成為細菌感染療法的新方向。此重要發現於8月21日發表於《自然通訊》(Nature Communications) 期刊。