"𝐀𝐧𝐝 𝐬𝐨 𝐚𝐥𝐥 𝐭𝐡𝐞 𝐰𝐨𝐫𝐥𝐝𝐬 𝐭𝐡𝐞 𝐥𝐢𝐭𝐭𝐥𝐞 𝐠𝐢𝐫𝐥 𝐩𝐥𝐚𝐲𝐞𝐝 𝐩𝐫𝐞𝐭𝐞𝐧𝐝 𝐢𝐧 - 𝐰𝐞𝐫𝐞 𝐭𝐡𝐞 𝐨𝐧𝐞𝐬 𝐫𝐚𝐢𝐬𝐞𝐝 𝐢𝐧𝐭𝐨 𝐞𝐦𝐩𝐢𝐫𝐞𝐬 𝐰𝐡𝐞𝐧 𝐬𝐡𝐞 𝐠𝐫𝐞𝐰 𝐮𝐩."
▫️
▫️
WERE YOU A WEIRD KID TOO?
A lovely old friend who knew me from primary school shared that I'd always been a... different kind of kid. As many of you here were!
I wrote poems about the Japanese Occupation in Primary 2, and was constantly creating clubs for all things whimsical. Faeries. Mermaids. The Romanovs (lol). Princesses. She's always been someone whose opinion I respected, so I was touched to hear that she thought this.
But then, also... I remember being ostracised by other kids at school for being different. One of the phrases consistently used by most of my teachers to refer to me was "airy fairy". "up in the clouds". I was WARNED to try and be less so, by a well meaning teacher, who told me the staffroom had been talking about me. I remember always feeling like a heart shaped peg made to fit into a square hole. I'm sure many of us felt this way.
I treasure the rare, perceptive few teachers who understood this simple truth: that different kids have different strengths.
Was tasked to create a project about the heliocentric model of the universe. Wrote a ditty about Copernicus. My physics teacher played it proudly for the class & featured it in the science fair. In uni, was tasked to write projections about the future of genetics. Turned in a dystopian novella. My biomolecular science prof sent a copy to the whole class to read. And my humanities teachers & profs always made us arts kids feel like we were seen & acknowledged & RESPECTED, in a system that often didn't.
What I'm trying to say is: encourage kids to thrive in the way they do best. Don't stifle creativity and don't write off innovative imagination as impracticality or dysfunction. Our world is going to need a GENERATION of unique thinkers to creatively problem-solve the world we've left for them to inherit. Today's dreamer may become tomorrow's pioneer, or humanitarian, or healer, or world leader, or tech genius. Or maybe even... mermaid flunkey? 😂you never know. You really never know.
同時也有10000部Youtube影片,追蹤數超過2,910的網紅コバにゃんチャンネル,也在其Youtube影片中提到,...
「write-off meaning」的推薦目錄:
- 關於write-off meaning 在 Syrena- Singapore's First Mermaid Facebook 的精選貼文
- 關於write-off meaning 在 台灣光鹽生物科技學苑 Facebook 的精選貼文
- 關於write-off meaning 在 コバにゃんチャンネル Youtube 的最佳解答
- 關於write-off meaning 在 大象中醫 Youtube 的最讚貼文
- 關於write-off meaning 在 大象中醫 Youtube 的最佳貼文
- 關於write-off meaning 在 英文成語write off 是甚麼意思? 這句話看起來很 ... 的評價
- 關於write-off meaning 在 Write-off Meaning - YouTube 的評價
write-off meaning 在 台灣光鹽生物科技學苑 Facebook 的精選貼文
<生醫新聞>Cyclacel臨床三期的急性骨髓性白血病藥物在關鍵研究中失敗
#AcuteMyeloidLeukemia #FailedTrials #ClinicalResearch #Cyclacel #Decitabine #Sapacitabine #FDA
Cyclacel Pharmaceuticals has been taught the meaning of futility. Two years after an independent data monitoring board told Cyclacel its phase 3 acute myeloid leukemia (AML) trial was destined to fail, the ever-optimistic biotech has reported its drug sapacitabine was unable to better the active control in terms of overall survival.
The top-line data confirm an outcome that looked likely from the minute independent advisers told Cyclacel the study had failed an interim futility review in December 2014. By then, the phase 3 trial had chalked up 247 of the 424 patient deaths needed to trigger the end of the study. But, with the review finding no safety issues that would force Cyclacel to shutter the study, the NJ-based biotech pushed ahead regardless.
A little more than two years later, Cyclacel has learnt sapacitabine is no better at improving overall survival in elderly patients with AML than decitabine, an Otsuka drug FDA rejected in the indication in 2012 on the basis that it also failed to outperform the control arm in its own study. Decitabine, sold under the name Dacogen as a treatment for myelodysplastic syndromes, is used off-label in elderly AML patients because of the dearth of options in this population.
When combined with the performance of sapacitabine against some secondary endpoints, the lack of options for elderly patients with AML who cannot or will not undergo chemotherapy has given Cyclacel encouragement to continue seeking a way forward for the drug.
“We plan to discuss the data with European and U.S. regulatory authorities once subgroup analyses are completed over the next few months and will report our further plans as they develop,” CEO Spiro Rombotis said in a statement.
Rombotis and the chair of the phase 3, MD Anderson’s Hagop Kantarjian M.D., picked out the data on complete remission and safety as cause for optimism. Kantarjian, a critic of FDA’s decision to reject decitabine in AML, called the improved rate of complete remission “remarkable.” Cyclacel said the safety of the two arms was similar.
While Rombotis and Kantarjian see the data as suggesting it is still too early to write off sapacitabine, investors were less optimistic. Cyclacel dropped 30% in premarket trading, adding further woes to a stock that is down 99% on the highs it hit a decade ago. The company’s market cap prior to news of the latest setback stood at $24 million.
資料來源:http://www.fiercebiotech.com/…/cyclacel-aml-drug-fails-phas…
write-off meaning 在 Write-off Meaning - YouTube 的推薦與評價

Video shows what write - off means. The cancellation of an item; the amount cancelled or lost. Something that is now worthless (such as a car ... ... <看更多>
write-off meaning 在 英文成語write off 是甚麼意思? 這句話看起來很 ... 的推薦與評價
英文成語write off 是甚麼意思? 這句話看起來很簡單,意思也不難懂,但就是不好翻譯: 1認定。 Doctors tend to write off dizziness as an inevitable ... ... <看更多>