關於 germline ，我們在網路上蒐集到這些相關的討論、資訊與評價

#11. Identifying germline mutations associated with cancer risk and ...

Whole-genome sequencing provides a comprehensive picture of germline mutations across the entire cancer genome. Targeted sequencing studies use hereditary ...

#12. Broad-based testing increases detection of inherited germline ...

Universal germline genetic testing found that 13.3% of study participants harbored a pathogenic germline variant — 48% of which would not ...

#13. GERMLINE - Computer Science, Columbia University

NOTE: Although the PLINK format is not intended for haplotypes, GERMLINE expects the respective alleles to appear in order; i.e. the first allele always ...

#14. The deteriorating soma and the indispensable germline

The idea that there is an impenetrable barrier that separates the germline and soma has shaped much thinking in evolutionary biology and in ...

#15. Germline - 博客來

Germline (n): the genetic material contained in a cellular lineage that can be passed to the next generation. Also (slang): secret military program to ...

#16. International Commission on the Clinical Use of Human ...

In addition, other important discussions are ongoing internationally about the implications for society of human germline genome editing and include issues such ...

#17. Germ line Definition & Meaning - Merriam-Webster

The meaning of germ line is the cellular lineage of a sexually-reproducing organism from which eggs and sperm are derived; also : the genetic material ...

#18. From Germline Stem Cells to Gametes - Frontiers

During germline development, conserved signaling pathways, including Notch, Wnt, JAK-STAT, and TGFβ, promote mitotic division of germ cells at ...

#19. Germline Mutations in Predisposition Genes in Pediatric Cancer

Conclusions. Germline mutations in cancer-predisposing genes were identified in 8.5% of the children and adolescents with cancer. Family history ...

#20. Human germline genome editing commission | Royal Society

International commission on the clinical use of human germline genome editing. Commission co-chairs. Kay Davies (left) and Richard Lifton (second from left), co ...

#21. Somatic vs Germline Mutations | BioNinja

Somatic vs Germline Mutations · Somatic mutations – occur in a single body cell and cannot be inherited (only tissues derived from mutated cell are affected) ...

#22. Germline Variant Analysis - University of Utah Health Sciences

Germline. Germline genotyping and sequencing are used in disease gene discovery research and clinical genetic testing. Detection of germline variants ...

#23. Somative vs Germline Testing - InformedDNA

Patient-Centered Cancer Care: Somatic vs. Germline Testing and the Role of Genetic Counselors · Somatic mutations (or acquired mutations) are ...

#24. Germline Genetic Testing for Breast Cancer Risk - ASCO ...

Furthermore, polygenic risk scores (PRSs) to predict BC risk in patients with or without germline mutations in cancer-predisposition genes are ...

#25. Germline stem cell marker guide | Abcam

... we have outlined spermatogenesis markers present throughout each stage of germline stem cell differentiation. From primordial germ cells to spermatids, ...

#26. Germline and Somatic Mutations: What Is the Difference?

Germline variants are far less common, accounting for only about 5%–10% of all cancers. A germline variant occurs in a sperm cell or an egg ...

#27. Germline Cells Shown to be Vulnerable during Pregnancy

A new study furthers the understanding of the human germline — the cells that create eggs or sperm in humans during prenatal development.

#28. Germline cells - Higher Human Biology Revision - BBC

gametes. The nucleus of a germline stem cell undergoes two divisions, firstly separating homologous chromosomes and secondly separating chromatids.

#29. Medical Definition of Germline mutation - MedicineNet

Germline mutation: A heritable change in the DNA that occurred in a germ cell (a cell destined to become an egg or in the sperm) or the ...

#30. Unexpected 'Germline' Plant Cells May Shield New Generations

The nuclei of male germline cells at different stages of development appear green. Courtesy Říha Lab. Plants, however, are different.

#31. What are genome editing and CRISPR-Cas9? - MedlinePlus

Germline cell and embryo genome editing bring up a number of ethical challenges, including whether it would be permissible to use this ...

#32. 14.9: Germline vs. Soma - Biology LibreTexts

Deciding between germline and soma. What determines. which of the early cells of the embryo will be destined to go on to form sperm or eggs, ...

#33. Protecting and Diversifying the Germline | Genetics

Throughout oogenesis and spermatogenesis, germ cells are closely associated with somatic gonadal cells. In females, germline stem cells (GSCs) ...

#34. Germline soma communication mediated by gap junction ...

Further, we show that somatic follicle cells and germline nurse cells communicate through calcium fluxes that activates STAT in the follicle ...

#35. Human germline editing in the era of CRISPR-Cas - BMC ...

Three problems regarding germline therapies have been consistently discussed in ethics and law: (i) questions of risk and uncertainty related to ...

#36. Germline Recombination in the Mouse | Sloan Kettering Institute

Unlike its DNA repair role in somatic cells, homologous recombination has a distinct role in meiosis in ensuring proper chromosome segregation. In yeast, an ...

#37. Germline chromatin - WormBook

Histone methylation can correlate with silenced DNA (H3methK9, H3methK27), or with active DNA (H3methK4, H3methK36). 3. Embryonic germline chromatin. 3.1. The P ...

#38. Germline burden of rare damaging variants negatively affects ...

In this study, we focused specifically on the association of germline PTV burden with lifespan and disease-free survival, and estimated the ...

#39. Germline and Pluripotency | Harry Leitch - MRC London ...

We are interested in how the germline is established during primordial germ cell (PGC) development, and how this goes wrong leading to either infertility or ...

#40. The mammalian germline as a pluripotency cycle - Journals ...

Germline cycle. Cycle from zygote through primordial germ cells to gametes and new zygote that ensures transmission down the generations, in ...

#41. Germline Database Working Group - The Antibody Society

The WG works to establish processes for documenting novel germline genes and alleles and standards for versioned, inclusive databases. The WG also provides ...

#42. Germline Mosaicism - Parent Project Muscular Dystrophy

Germline carriers: females who have the genetic mutation only in their ovaries/eggs. If a woman has a child with Duchenne and she has genetic carrier testing ...

#43. Nordic Guidelines for Germline Predisposition to Myeloid Neo...

Diagnostic genetic testing for germline variants in patients with MDS or AML may be performed by the clinical/medical geneticist as part of genetic counseling ...

#44. PE2960 Somatic and Germline Cancer Testing - Seattle ...

Somatic and Germline. Cancer Testing. Pre-Test Genetic Counseling Information. What is genetic testing? Genetic testing looks for specific changes ...

#45. Is germline gene therapy ethical? | Debates | yourgenome.org

Germline gene therapy is when DNA is transferred into the cells that produce reproductive cells, eggs or sperm, in the body.

#46. Human Germline and Heritable Genome Editing: The Global ...

Germline genome editing research can be conducted with aims that include understanding the development of human embryos, the reasons for ...

#47. Germline Development - 第 49 頁 - Google 圖書結果

There's no evidence that other somatic gonad cells affect germline proliferation, although it remains a possibility. If mes-2, mes-3, mes-4 and/ or mes-6 ...

#48. Engineering the Human Germline: An Exploration of the ...

So, you have posed a complex question about the role that religion plays in evaluating germline engineering and genetic technologies. The answer is complex, ...

#49. Human Germline Modification and the Right to Science: A ...

With regard to the clinical use of germline genome modification, the Human Cloning Regulation Law and the related 2003 Guidelines prohibit pronuclear ...

#50. germline - Wiktionary

EnglishEdit. EtymologyEdit · germ +‎ line. NounEdit. germline (plural germlines). Those cells of an individual that have genetic material that could be ...

#51. Germline, spécialiste de la germination et de l'alimentation ...

Production et commercialisation de graines germées fraîches prêtes à l'emploi de type conventionnelle ou biologique.

#52. Myeloid Neoplasms with Germline Predisposition - FullText

AML with germline CEBPA mutation was initially described in 2004 in a family from the UK [5]. CEBPA is a single exon gene in the chromosomal ...

#53. Germline (The Subterrene War Book 1) Kindle Edition

Germline (The Subterrene War Book 1) - Kindle edition by McCarthy, T. C.. Download it once and read it on your Kindle device, PC, phones or tablets.

#54. Somatic/Germline Variant Curation - ClinGen

Integrating somatic variant data and biomarkers for germline variant classification in cancer predisposition genes. Publications - October 11, 2018.

#55. 5 Questions: Kelly Ormond on creating ground rules for ...

Germline gene editing raises a host of technical and ethical questions ... and that future clinical germline genome editing in humans not ...

#56. | Somatic vs. Germline Insertions. Differences between the ...

Differences between the heritability of germline vs. somatic retrotransposon insertions. (A) Somatic insertions lead to mosaicism within the individual but are ...

#57. High prevalence of germline variants in Japanese patients ...

Certain kinds of tumors can be inherited within families. Identifying the underlying genetic cause is important in treatment, ...

#58. ASGCT Statement on Germline Gene Editing Practices

The American Society of Gene @ Cell Therapy (ASGCT) @considers it@wholly unacceptable@to@consider germline gene-editing and the implantation ...

#59. Reexamining the Ethics of Human Germline Editing in the ...

The editing of the human germline for reproductive purposes should be understood against an historic backdrop of clinical research in ...

#60. The Difference Between Germline & Somatic Mutations

When a mutation occurs in a germ cell, it is called germline mutation. Since these mutations occur in the cells that create gametes, the mutations can be passed ...

#61. Tumor sequencing panel screens for both somatic and ...

Not all individuals with germline mutations meet evidence-based testing guidelines. Routine screening of both tumor tissue (to look for somatic ...

#62. Human Inheritable Genetic Modifications Assessing Scientific ...

American Association for the Advancement of Science. Mark S. Frankel. Audrey R. Chapman. September 2000 http://www.aaas.org/spp/dspp/sfrl/germline/main.htm ...

#63. germline 中文 - 查查在線詞典

最后，我應當提一句生殖系基因療法。 germline gene therapy 生殖細胞基因治療; This experiment shows this eg cell line is pluripotent, germline transmission remains ...

#64. Germline mutation - Ordbog - Kræftens Bekæmpelse

En germline mutation er en genændring i kroppens kønsceller (mandens sæd og kvindens æg). Derfor bliver germline mutationer givet videre til ens børn, ...

#65. Three Novel EPAS1/HIF2A Somatic and Germline mutations ...

We now report on these three patients, two with different tumor somatic codon A530 HIF2A mutations in exon 12 and one with germline mutation ...

#66. Germline and Somatic Mutations in Advanced Prostate Cancer

Germline mutations are found in sperm only, whereby the entire organism carries the mutation, and half of the gametes carry the mutation.

#67. Survey Reveals Groups, Strategies to Focus Awareness ...

The survey focused on awareness of germline testing, like screening for mutations in BRCA1/2 to assess the risk of breast cancer and ...

#68. [유전학 중요개념 정리] Germline vs. Somatic mutation - 두마디 ...

... 이번 포스팅에서는 Germline mutation (생식 세포 돌연변이)와 Somatic mutation (체세포 돌연변이)의 개념과 임상적 중요성에 대해서 정리하려고 ...

#69. The Prickly Debate on Germline Gene Therapy, and Moving It ...

Germline gene therapy has the ability to prevent diseases from being passed on not only to one child, but to all future generations.

#70. Genetic Testing for Prostate Cancer | NJU - New Jersey Urology

“Germline” mutations are DNA mutations that are inherited from one's mother, father, or both parents. These inherited mutations have been ...

#71. Male Germline Stem Cells: Developmental and Regenerative ...

The integrated view for the stem cell niche system was established substantially in the Drosophila germline stem cells (GSCs) in both the testis and ovary ...

#72. Rare Pathogenic Germline Variants Were Observed in ...

Furthermore, the presence of a pathogenic or likely pathogenic germline variant in a cancer predisposition gene was associated with worse ...

#73. An Exploration of the Science and Ethics of Altering the Genes ...

Engineering the Human Germline: An Exploration of the Science and Ethics of Altering the Genes We Pass to Our Children - Ebook written by Gregory Stock, ...

#74. Genetics 101 - KinTalk

沒有這個頁面的資訊。

#75. Germline vs. Soma - Kimball's Biology Pages

Germline vs. Soma. Could a mutation in one of your liver cells ever be passed on to your children? No! Why not? The fusion of one sperm cell and one egg ...

#76. What is Somatic and Germline Mutation? - Genetic Education

"Somatic mutations occur in somatic cells and can't be inherited whilst the germline mutations occur in germ cells and inherited onto ...

#77. Arrival of Gene-Edited Babies: What lies ahead? - Science in ...

DNA editing made in germline cells (gray) will be passed down to all further generations. Advent of CRISPR: Genome editing 2.0. In 2012, 40 ...

#78. Germline | LinkedIn

Germline | 351 abonnés sur LinkedIn. "Les graines germées, c'est la vie !" | GERMLINE, c'est l'expert français de la graine germée bio sous tous les formes ...

#79. World Pancreatic Cancer Day Q&A with Dr. James Farrell

... of developing pancreatic cancer due to either their family history of pancreatic cancer or an inherited germline mutation such as BRCA2.

#80. Germline variants and breast cancer survival in patients with ...

Escala-Garcia, M., Canisius, S., Keeman, R., Beesley, J., Anton-Culver, H., Arndt, V., Augustinsson, A., et al. (2021). Germline variants ...

#81. Germline alterations in the CDH1 gene in familial gastric ...

Germline point or small frameshift mutations of the CDH1 (E-cadherin) gene are known to cause familial gastric cancer (FGC), but the frequency of CDH1 ...

#82. germline 是什么意思，中文意思| 种系英文怎么说| 生物学| 遗传学

LetPub推出的科学术语在线词典汇集了最全面的专业术语词汇翻译，SCI论文对照, 包括多种学科领域。如中医常用医学名词，传染病学名词，儿科医学名词，内科学专业名词， ...

#83. Germ Cell Development - iBiology

Part 2: Establishing Soma-Germline Dichotomy ...

#84. #germline - Twitter Search / Twitter

The latest Tweets on #germline. ... We are going to explore how annelid worms regenerate their germline using live imaging, transgenics, and single cell ...

#85. Journal of Medical Genetics - A leading BMJ journal for ...

Articles cover the molecular basis of human disease including germline cancer genetics, clinical manifestations of genetic disorders, applications of ...

#86. Germline and Somatic Tumor Testing in Gynecologic Cancer ...

Inherited or germline mutations occur in germ cells, and thus allow a deleterious mutation to be transmitted to progeny in an autosomal-dominant ...

#87. germline 中文

germline 中文 · Germline Catch™ · ACTBRCA® 貝癌檢™癌症基因檢測 · GWAS · drivers mutation_百度百科.

#88. Cancer Screening Recommendations for Individuals with Li ...

Li-Fraumeni syndrome (LFS) is an autosomal dominantly inherited condition caused by germline mutations of the TP53 tumor suppressor gene ...

#89. Invitae: Medical genetic testing experts trust

Your health starts in your genes. Invitae (“in-VEE-tay”) makes it easy to access your unique genetic information, so you can take control of your health.

#90. GERMLINE 2-jų aukštų daigykla

Germline 2-jų aukštų daiginimo indai - tai universalios daigyklos, tinkančios daiginti sėklas ir kruopas. Germline daiginimo indu naudotis labai paprasta!

#91. TWiV 821: Public clonotype #1 - Microbe.TV

... and isolation of naive B cells from seronegative donors that produce germline encoded antibodies which engage the receptor binding ...

#92. VarSome The Human Genomics Community

Some useful examples to help you get started · Germline Variants · Cancer Variants · with AMP classification · Genes · Transcripts · Transcript / Genomic Position.

#93. 生殖细胞系本文重定向自germline - 万维百科

生殖细胞系（germline）又称生殖细胞谱系、生殖系、种系、生殖株，是一个生物学及遗传学的名词，指生殖细胞的谱系，即多细胞生物中能繁殖后代的一类细胞聚落的总称， ...

#94. somatic vs germline mutation - Positive Bioscience

Cancer patients are often prescribed mutation testing. Most cancer testing is done on somatic mutations but germline mutations also play a ...

#95. Color: COVID-19 and Genetic Testing for Populations

From population genomics to high throughput COVID-19 testing, Color provides the technology & infrastructure for large scale health initiatives. Learn more.

#96. A thought-provoking look at the gene-editing revolution | Bill ...

But some scientists are not treating the germline as a red line. As Isaacson covers with nuance, three years ago a Chinese researcher named He ...