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#1. Techniques to Induce and Quantify Cellular Senescence - PMC
由 NN Hooten 著作 · 2017 · 被引用 117 次 — 1. Inducing Replicative Senescence. Thaw low-passage human diploid fibroblasts (e.g., WI-38 and IMR-90) or other cell lines.
#2. Small molecule compounds that induce cellular senescence
Cellular senescence is a stable arrest of the cell cycle and is characterized by complex phenotypic changes. It was first described in studies ...
#3. Mechanisms of Cellular Senescence: Cell Cycle Arrest and ...
由 R Kumari 著作 · 2021 · 被引用 82 次 — Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in response to various intrinsic and extrinsic ...
#4. Methods of Cellular Senescence Induction Using Oxidative ...
Human diploid fibroblasts offer a typical model for studying cell senescence in vitro. Various approaches to evoke oxidative stresses, such as the exposures of ...
#5. Methods of Cellular Senescence Induction Using Oxidative ...
Hydrogen peroxide is widely used to achieve oxidative stress-induced premature senescence within a short period of time. Such induced premature senescent cells ...
#6. Mechanisms and functions of cellular senescence - JCI
Indeed, senescence can be engaged during development (6, 7) and is also necessary for tissue remodeling. For instance, transient induction of ...
#7. The Effects of Oxidative Stress on Inducing Senescence in ...
exposure to induce the greatest number of senescent cells. ... of senescent cells due to the accumulation of reactive oxygen species.
#8. High doses of synthetic antioxidants induce premature ...
Stress-induced premature senescence program is known to be activated in cells by various genotoxic stressors, and oxidative stress is ...
#9. Senescence in the Lab: Induction and Biomarkers - SENS ...
First, we know that cellular senescence can be induced by direct damage to a cell's DNA, telomeres - or the protective caps at the end of DNA molecules, ...
#10. Cellular senescence - Wikipedia
Cells can also be induced to senesce by DNA damage in response to elevated reactive oxygen species (ROS), activation of oncogenes, and cell-cell fusion.
#11. Stress, cell senescence and organismal ageing - ScienceDirect
Later, pioneering work by Olivier Toussaint and others showed that stress plays a major role in the induction of senescence in vitro, a phenomenon known as ...
#12. Senescence and apoptosis: dueling or complementary cell ...
In response to a variety of stresses, mammalian cells undergo a persistent proliferative ...
#13. Mechanisms and Regulation of Cellular Senescence - MDPI
There are different types of senescent cells, and senescence can be induced in response to many DNA damage signals. Senescent cells accumulate ...
#14. Doxorubicin Induces Senescence in Intestinal Epithelial Cells
Doxorubicin induces cellular senescence in numerous cell types as part of its mechanism of action.(8–11) In these cells, DXR-induced senescence ...
#15. Rapid induction of senescence in human cervical carcinoma ...
In this paper, we show that E2-mediated repression of the HPV E6/E7 genes induced cervical carcinoma cells to rapidly assume the phenotype of senescent ...
#16. Glucocorticoids induce senescence in primary human ...
First observed in aged cells, cell senescence can also occur in young cells usually as a consequence of activation of either/both of the p38/p16 INK4a or p53/p21 ...
#17. Cellular Senescence Is Induced by the Environmental ...
induce astrocytic senescence and an SASP in vitro and in vivo, and senescent cell depletion in the latter protects against PQ-induced ...
#18. Overview of Cellular Senescence and Aging - Cell Signaling ...
Cellular senescence refers to a state of stable cell cycle arrest in which proliferating cells become resistant to growth-promoting stimuli, typically in ...
#19. Metformin alleviates stress-induced cellular senescence of ...
Aging is associated with stress-induced senescence of adipose stromal cells, leading to impaired adipogenesis, oxidative stress, ...
#20. Control of cellular senescence by CPEB - Genes & Development
Senescence is a process that limits the number of times a cell divides in vitro; in mouse cells, it can be induced by DNA damage, the activation of certain ...
#21. Quercetin-induced apoptosis ameliorates vascular smooth ...
While senescent cells are observed to be in a state of irreversible growth arrest, they remain metabolically active. This cellular senescence is ...
#22. Cellular senescence in development, regeneration and disease
Cellular senescence is a form of permanent cell cycle arrest that can be induced in primary cells in response to a variety of stimuli.
#23. Stable Cellular Senescence Is Associated with Persistent ...
Cellular senescence is a permanent cell cycle arrest ... Oncogene-induced senescent cells (OIS BJ cells) were obtained and grown as in [21].
#24. Subtoxic Oxidative Stress Induces Senescence in Retinal ...
conclusions. Oxidative stress, TGF-β1, and TGF-β2 are capable of inducing cellular senescence in cultured human RPE cells. Therefore, reduction of oxidative ...
#25. Ras Proteins Induce Senescence by Altering the Intracellular ...
A more dramatic rescue of V12Ras-expressing cells is demonstrated when the cells are placed in a low oxygen environment, a condition in which reactive oxygen ...
#26. DNA Damage Is Able to Induce Senescence in Tumor Cells in ...
Thus, like apoptosis, senescence appears to be a p53-induced cellular response to DNA damage and an important factor in determining treatment outcome.
#27. Cellular Senescence | Life Science Research - Merck Millipore
As one would guess, the DNA damage and oxidative stress responses, via p53 and AMPK, induce senescence via the retinoblastoma pathway. And telomere shortening ...
#28. Therapy-Induced Senescence: Opportunities to Improve ...
Induction of tumor cell senescence is also one of the underlying mechanisms by ...
#29. Chemotherapy-induced senescent cancer cells engulf other ...
In chemotherapy-treated breast cancer, wild-type p53 preferentially induces senescence over apoptosis, resulting in a persisting cell ...
#30. Senescence induction; a possible cancer therapy
Cellular senescence is a process that is triggered not only by telomeric erosion but also by other forms of stress. Several factors provoke ...
#31. Assessing Cell and Organ Senescence Biomarkers - AHA ...
Rb/p16 and p53/ARF are major cellular pathways involved in cellular arrest and oncogene-induced senescence. Mutations in any of these two tumor ...
#32. Weak p53 permits senescence during cell cycle arrest
Nutlin-3a-induced p53 inhibited mtoR and thus caused quiescence in WI-38 cells. In contrast, while arresting cell cycle, the DNA-damaging drug ...
#33. Senescent Human Fibroblasts Show Increased Glycolysis and ...
Senescent cells can also induce DSBs12 and senescence13 in ... human aging or cellular senescence cells in vivo. The data also.
#34. Possibility of inducing tumor cell senescence during therapy ...
There are multiple factors that regulate this process and cellular senescence is activated by various pathways. Senescent cells present specific ...
#35. The unfolded protein response and cellular senescence. A ...
Senescence is a complex cell phenotype induced by several stresses such as telomere attrition, DNA damage, oxidative stress, and.
#36. Mitochondrial Dysfunction Contributes to Oncogene-Induced ...
Ras-induced senescence can be inhibited by using antioxidants or growing cells in low-oxygen conditions (8, 25, 33, 51).
#37. Senescence, oxidative stress and mitochondria dysfunction
The characteristics of senescent cells include enlargement and flattened phenotype, ... Deletion of PTEN also induces senescence (known as PTEN-induced cell ...
#38. Molecular Mechanisms of Cellular Senescence | IntechOpen
Usually induced by telomere shortening this form of arrest is irreversible in the sense that cells cannot be triggered to re-enter proliferation by ...
#39. Cellular Senescence: Mechanisms, Morphology, and Mouse ...
Although this represents a critical mechanism of tumor suppression, persistence of senescent cells during aging induces chronic inflammation ...
#40. Connecting Metabolism and Cellular Senescence
SASP, which can promote inflammation and the proliferation of tumor cells that escape the chemotherapy-induced senescence. Together, these studies suggest a ...
#41. Cellular senescence: a promising strategy for cancer therapy
Exposure of cancer cells to chemotherapeutic drugs or ionizing radiation also induces a senescent response, termed therapy-induced senescence (TIS) (9, 10).
#42. Cellular Senescence as a Target in Cancer Control - Hindawi
This indicates that at a certain point of lineage differentiation, cells activate the senescence clock that ultimately induces cell senescence through a ...
#43. Cellular Senescence: What, Why, and How - HMP Global ...
Cellular senescence refers to the essentially irreversible arrest of cell proliferation (growth) that occurs when cells experience potentially oncogenic stress.
#44. Senescence: What is it? What's a new way to study it?
Senescent cells are cells that have stopped dividing due to telomere ... Senescence was induced in T47D, human epithelial cells by treating ...
#45. Cellular Senescence Reagent Selection Guide - Dojindo EU ...
The induction and control mechanisms of cellular senescence - in which genetic and external factors are intricately involved - have yet to be fully ...
#46. Stress-induced premature senescence mediated by a novel ...
Abstract. Cellular senescence is a mechanism to inhibit the growth of mammalian cells after oncogenic activation, or in response to damage or stress.
#47. Senescence in Post-Mitotic Cells: A Driver of Aging?
First, tumor cells can be induced to senesce by DNA-damaging therapies; however, after having developed a senescent phenotype, some of these ...
#48. Cell Senescence: Role in Aging and Age-Related Diseases
In senescent cells engaged in the SASP phenotype, inactivation of p53 by RNA interference produced an important accentuation of SASP induction ...
#49. Ageing, cellular senescence and the impact of diet: an overview
Obesity is a metabolic condition that can accelerate the ageing process by promoting a premature induction of the senescent state of the cells.
#50. The emerging role of cell senescence in atherosclerosis - De ...
Replicative senescence is characterized by telomere shortening, whereas stress-induced premature senescence is mainly due to oxidative stress ...
#51. Expression of Caveolin-1 Induces Premature Cellular ...
Interestingly, we show that subcytotoxic level of hydrogen peroxide induces premature senescence in NIH 3T3 cells and increases endogenous caveolin-1 ...
#52. Oxidative stress, cellular senescence and ageing - AIMS Press
The exact mechanism of ROS and oxidative stress-induced age-related ... and its possible role in the ageing process via induction of cellular senescence.
#53. Autophagy Is Pro-Senescence When Seen in Close-Up, but ...
to restore PML-induced cellular senescence in tumor cells and this is well correlated with an increase in autophagy that.
#54. Linking senescence with DNA Damage and the cell cycle
#55. Why we Age: Cellular Senescence | Lifespan.io
Researchers first tested the idea of targeting senescent cells to selectively induce apoptosis by engineering special mice that were designed to react to a ...
#56. Senescent Cells And Senescence In Plants - Byjus
This cellular program induces stable growth arrest. The ageing process, on the whole, can be classified into three groups: Causes of age-associated damage – ...
#57. International Cell Senescence Association
Cellular senescence is a programmed state of stable cell cycle arrest that is accompanied by a complex phenotype. Senescent cells play a role in physiological ...
#58. Telomeres and cell senescence (video) | Khan Academy
#59. Tuberculosis induces premature cellular aging - ScienceDaily
Increased DNA methylation, cellular senescence and premature epigenetic aging in guinea pigs and humans with tuberculosis. Aging, 2022; 14 (5): ...
#60. Study finds tuberculosis can induce premature cellular ageing
These changes correlated with oxidative stress-induced senescence and was associated with premature cellular ageing.
#61. Study finds tuberculosis can induce premature cellular ageing
These changes correlated with oxidative stress-induced senescence and was associated with premature cellular ageing.
#62. Radiotherapy orchestrates natural killer cell dependent ...
In experimental models, NF-κB and mTOR orchestrated radiation-induced CXCL8 secretion from tumor cells with senescence features causing ...
#63. Tuberculosis induces premature cellular aging - Baylor ...
It's possible that premature cellular aging in TB is one reason why ... changes correlated with oxidative stress-induced senescence, ...
#64. Tuberculosis perturbs epigenetic processes to promote ...
These changes correlated with oxidative stress-induced senescence and was associated with premature cellular aging.
#65. Tuberculosis can Induce Premature Cellular Ageing - News18
These changes correlated with oxidative stress-induced senescence and was associated with premature cellular ageing.
#66. Tuberculosis induces premature cellular aging | EurekAlert!
“It's possible that this premature cellular aging is one reason why ... These changes correlated with oxidative stress-induced senescence ...
#67. Expression profiles of DNMT1-interacting proteins in the ...
Similar results were obtained in the stress-induced senescence triggered by ... and their contribution to cell senescence are currently under investigation.
#68. Tuberculosis can induce premature cellular ageing, new study ...
Cells in humans and animals who have recovered from tuberculosis ... stress-induced senescence and correlate to premature cellular ageing.
#69. Tuberculosis survivors must battle premature cellular ageing ...
Tuberculosis or TB causes premature ageing of cells, ... These changes correlated with oxidative stress-induced senescence and was ...
#70. Identifying the miRNA signature association with aging-related ...
Evidences suggest that signaling pathways of stem cells are also ... with stress induced senescence, significant miRNA targets for cell cycle arrest, ...
#71. Oxidative stress-induced circKIF18A downregulation impairs ...
In this study, we found that oxidative stress was positively correlated with nucleus pulposus cell (NPC) senescence in IVDD and that circKIF18A ...
#72. Koji Itahana - Duke-NUS Medical School
... role for p53 in cellular senescence, and at the laboratory of Dr. Yanping Zhang, ... After he started his own laboratory at Cancer & Stem Cell Biology ...
#73. NIH Public Access
Human lung epithelial cells progressed to malignancy through ... function is required to prevent oncogene-induced senescence; 5) over-expression of c-MYC.
#74. Instrument Citation Search Tool | Bio-Techne
(2021) Aging increases senescence, calcium signaling, and extracellular matrix ... inhibit cancer cell proliferation and induce caspase mediated apoptosis.
#75. Study finds tuberculosis can induce premature cellular ageing
To measure the ageing of the cells, researchers looked at the ... These changes correlated with oxidative stress-induced senescence and was ...
#76. Tuberculosis induces premature cellular aging | Mirage News
These changes correlated with oxidative stress-induced senescence and was associated with premature cellular aging.
#77. a sensor of cells' response to CAP treatment with double ...
Cold atmospheric plasma causes a calcium influx in melanoma cells triggering CAP-induced senescence. Sci Rep. 2018;8:10048. 7. Xiang L, Xu X, Zhang S, ...
#78. Chronic obstructive pulmonary disease and atherosclerosis
The mechanisms linking these COPD-induced pulmonary and systemic ... enhanced apoptosis and cellular senescence, which may explain why these ...
#79. Research team finds that tuberculosis induces premature ...
These changes correlated with oxidative stress-induced senescence and was associated with premature cellular aging.
#80. 文章详细信息 - 生命的化学
Baicalin inhibits the proliferation of nasopharyngeal carcinoma cells by regulating ... Baicalin induces cellular senescence in human colon cancer cells via ...
#81. Tuberculosis can induce untimely mobile ageing, new ...
Cells in people and animals who've recovered from tuberculosis ... stress-induced senescence and correlate to untimely mobile ageing.
#82. Tuberculosis Induces Premature Cellular Aging - Fuzzy Skunk
Increased DNA methylation, cellular senescence and premature epigenetic aging in guinea pigs and humans with tuberculosis. Aging, 2022; 14 (5): ...
#83. Teach Me in 10 – Cell Senescence, Aging and Disease With ...
#84. Tuberculosis induces premature cellular aging – NovLink
Increased DNA methylation, cellular senescence and premature epigenetic aging in guinea pigs and humans with tuberculosis. Aging, 2022; 14 (5): ...
#85. Cell Senescence: possible strategies and new insights Cellular ...
Cellular senescence can be defined as a form of permanent cell cycle arrest induced in primary cells in response to a variety of stimuli.
#86. Health News | Study Finds Tuberculosis Can Induce ...
Get latest articles and stories on Health at LatestLY. A new study by researchers at Baylor College of Medicine found that the cells of ...
#87. Cellular Senescence and Tumor Suppression
Currently the term “stress-induced premature senescence” is often used for senescence resulting from all cellular events other than telomere dysfunction ...
#88. Tumor Dormancy, Quiescence, and Senescence, Volume 2: Aging, ...
MLN4924 Induces Irreversible Cellular Senescence Our further study revealed that HCT-116, U87 and H1299 cancer cells underwent cellular upon exposure to ...
#89. Tuberculosis induces premature cellular aging - ScienceDaily
These changes correlated with oxidative stress-induced senescence and was associated with premature cellular aging.
#90. Autophagy and Senescence in Cancer Therapy
We showed that induction of senescence by DNA damaging agent (doxorubicin) increased cell ploidy. Polyploidization was accompanied by transient inactivation ...
#91. Cellular Senescence in Disease - 第 174 頁 - Google 圖書結果
Autophagic cell death restricts chromosomal instability during replicative crisis. ... A senescent cell bystander effect: Senescence-induced senescence.
#92. Apoptosis and Senescence in Vertebrate Development
FIGURE 1 | Different senescence induction methods and molecular pathways ... functions of crucial sub- populations of senescent cells, especially with novel ...
#93. Tuberculosis causes premature cell aging, study says - News7h
DNA methylation. These changes correlate with aging induced by oxidative stress and are associated with premature cellular senescence. These ...
#94. Study finds tuberculosis can induce premature cellular ageing
These changes correlated with oxidative stress-induced senescence and was associated with premature cellular ageing. These processes were ...
#95. The Role of Cellular Senescence in Health and Disease
Senescent cells typically secrete a complex set of factors known as ... In IPF, TGF-β1 can induce the overproduction of ECM components such as collagen and ...
#96. Tuberculosis Induces Premature Cellular Aging - Fast Media ...
Increased DNA methylation, cellular senescence and premature epigenetic aging in guinea pigs and humans with tuberculosis. Aging, 2022; 14 (5): ...
#97. Tuberculosis Induces Premature Cellular Aging - - Movies And ...
Increased DNA methylation, cellular senescence and premature epigenetic aging in guinea pigs and humans with tuberculosis. Aging, 2022; 14 (5): ...
#98. Jennifer Lemon - Research Scientist - Rna Diagnostics Inc.
Cellular responses in senescence and exposure to ionizing radiation were ... Radiation-Induced DNA Damage and the Relative Biological Effectiveness of ...
how to induce senescence in cells 在 Linking senescence with DNA Damage and the cell cycle 的推薦與評價
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