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絕緣子（英語：insulator）是真核生物基因組的調控元件之一，亦為一種邊界元件。功能為阻止臨近調控元件，對它所界定基因的啟動子起增強或者阻遏的作用。
#2. Insulators are fundamental components of the eukaryotic ...
Insulators are regulatory elements that can shelter genes from inappropriate regulatory interactions. Transgenic assays have helped to dissect ...
#3. Insulators: many functions, many mechanisms - Genes ...
“Insulator” is the name given to a class of DNA sequence elements that possess a common ability to protect genes from inappropriate signals emanating from ...
#4. Chromatin Insulators: A Role in Nuclear Organization ... - NCBI
由 J Yang 著作 · 2011 · 被引用 68 次 — Chromatin insulators are DNA-protein complexes with broad functions in nuclear biology. Based on the ability of insulator proteins to interact with each ...
#5. The insulation of genes from external enhancers and silencing ...
Insulators are DNA sequence elements that can serve in some cases as barriers to protect a gene against the encroachment of adjacent inactive condensed ...
#6. Insulators and domains of gene expression - ScienceDirect
由 T Ali 著作 · 2016 · 被引用 116 次 — The existence of such domains specifically requires the presence of domain boundaries to insulate the opposite activities of neighbouring ...
#7. The genetic insulator RiboJ increases expression of insulated ...
To circumvent the effects of unintended RNA leaders, constructs can be designed to include genetic insulators, which isolate parts from unwanted ...
#8. A Comprehensive Map of Insulator Elements for the ... - PLOS
We here present the genome wide identification of over 14,000 binding sites for 6 insulator-associated proteins. We demonstrate the existence of ...
#9. Controlling gene activation by enhancers through a drug ...
We expected that the CTCF-binding sites of the cassette would recruit CTCF and function as a topological insulator and that the tetO/tetR system ...
#10. A Chromatin Insulator Determines the Nuclear Localization of ...
Chromatin insulators might regulate gene expression by controlling the subnuclear organization of DNA. We found that a DNA sequence normally located inside ...
#11. Opbp is a new architectural/insulator protein required for ...
Opbp is essential for the expression of ribosomal protein genes in vivo and interacts with CP190 and its sequence-specific DNA motif via ...
#12. Identification of Genomic Sites That Bind the Drosophila ...
The gypsy insulator, a 350-bp element isolated from the ... Second, they protect gene expression from chromosomal position effects that ...
#13. The role of chromatin insulator elements in the control gene ...
Obiettivo. Chromatin insulators allow genes to maintain independent programmes of expression through the establishment of fixed chromatin boundaries.
#14. More than insulator: multiple roles of CTCF at the H19-Igf2 ...
It is a versatile protein that regulates gene expression by binding to DNA via its multiple zinc fingers (Filippova, 2008; Ohlsson et al., 2010; ...
#15. Insulators form gene loops by interacting with promoters in ...
Insulators of the Drosophila Abd-B gene can establish contact with a region upstream of the promoter that is required for proper enhancer- ...
#16. Genomic insulator elements and uses thereof - Google Patents
239000012212 insulator Substances 0.000 title claims abstract description 274 ... 238000001415 gene therapy Methods 0.000 claims description 23 ...
#17. The insulator factor CTCF controls MHC class II gene ...
As a transcriptional insulator, CTCF binding prevents the actions of an enhancer from acting on the promoter of a downstream gene (16).
#18. Mutation of a barrier insulator in the human ankyrin-1 gene is ...
In transgenic mice, flanking a mutant –108/–153 ankyrin gene promoter with the well-characterized chicken HS4 barrier insulator restored ...
#19. Insulators in Plants: Progress and Open Questions - MDPI
Another candidate plant insulator is the gypsy-like sequence found in the Arabidopsis genome, which displayed enhancer blocking effects when inserted between ...
#20. Insulators and boundaries: Versatile regulatory elements in ...
Gene regulation - Insulators and boundaries: Versatile regulatory elements in the eukaryotic genome. February 2001; Science 291(5503):447-50.
#21. Chromatin insulator elements: establishing barriers to set ...
Insulators can be defined as DNA elements that have a common ability to protect a gene from undesirable regulatory influences present in their ...
#22. Role of an insulator in testis-specific gene transcription
In round spermatids, the insulator function is relieved, thus facilitating the SP-10 gene transcription. Insulators act as enhancer blockers and/or barriers to ...
#23. Genetic insulator for preventing influence by another gene ...
A 16 bp polynucleotide sequence of Arabidopsis thaliana is a genetic insulator that can effectively isolate a transgene from positional effects of ...
#24. The Use of Chromatin Insulators to Improve the Expression ...
Vector–Genome Interactions. Two types of interactions. It is now widely recognized that integrating gene transfer vectors, such as those based ...
#25. An insulator with barrier-element activity promotes α-spectrin ...
When added to the minimal α-spectrin promoter, the region directed expression of a linked A γ-globin gene in erythroid cells at all developmental ...
#26. "Insulators: A “Safety Guard” for Genome Stability in <i ...
However, previous studies have revealed that not all insulator sites in the ... chromatin loops and gene transcription regulation, insulators might play yet ...
#27. Insulator: from chromatin domain boundary to gene regulation
An insulator or boundary element is a novel class of regulatory sequence and has properties consistent with a role in limiting enhancer activity; it helps.
#28. Identification and Characterization of Barrier Insulator Activity ...
For instance, heterochromatin could spread into a euchromatin region and lead to inappropriate silencing of active genes; or, long-range acting gene regulatory ...
#29. Genetic Insulator for Preventing Influence by ... - UKnowledge
genetic insulator that can effectively isolate a trans gene from ... a plant genetic insulator to control transgene expression in plants.
#30. The cHS4 Chromatin Insulator Reduces the Rate of Retroviral ...
Although most attention has focused on the activation of cellular genes by vector enhancers, aberrant fusion transcripts involving cellular gene ...
#31. Award # 0718898 - Analysis of Chromosomal Insulators and ...
One aim of this project is to study insulator function using genetic tools. Knockout mutations in the single gene encoding these two proteins and in the 32A ...
#32. A Novel CpG-free Vertebrate Insulator Silences the Testis ...
How these genes remain silent in the somatic tissues is not well understood. Our previous studies using the round spermatid-specific mouse SP-10 gene, which ...
#33. Genetic and Molecular Analysis of the gypsy Chromatin ... - jstor
ABSTRACT Boundary or insulator elements set up inde- pendent territories of gene activity by establishing higher order domains of chromatin structure.
#34. INSULATOR TO IMPROVE GENE TRANSFER VECTORS
(54) INSULATOR TO IMPROVE GENE TRANSFER VECTORS ... Gene silencing, most vectors loose their expression due to epigenetic modifications.
#35. Insulators: exploiting transcriptional and epigenetic mechanisms
A domain containing genes that are transcriptionally active in a particular cell type might lie close to another domain containing genes that ...
#36. retroviral gene therapy vectors including insulator elements to ...
Silencing of retrovirus vectors poses a significant obstacle to stem cell gene therapy, and may also impact stem cell marking and genetic manipulation ...
#37. Terminology of Molecular Biology for insulator - GenScript
GenSmart™ Codon Optimization. GenSmart Optimization is a free online tool for performing codon optimization to improve gene expression. · DNA Construct Design ...
#38. Review - Chromatin Insulators: Linking Genome Organization ...
gene expression. Here we discuss higher-order chromatin organization as a unifying mechanism for diverse insulator actions across the genome ...
#39. Chromatin Insulators | Annual Review of Genetics
Numerous insulators map to promoters of genes or have binding sites for transcription factors and like active chromatin hubs and silenced ...
#40. Insulator proteins contribute to expression of gene loci ...
Nevertheless, dozens of genes were embedded into pericentric genome regions during evolution of Drosophilidae lineage and retained functional ...
#41. The human ankyrin 1 promoter insulator sustains gene ...
The human ankyrin 1 promoter insulator sustains gene expression in a β-globin lentiviral vector in hematopoietic stem cells. Publication Type ...
#42. Control of insulator function and higher order genome ... - GtR
By altering chromatin structure and dynamics at insulators, wholesale remodeling of genome architecture and thus gene expression can be achieved.
#43. Insulators and Boundaries: Versatile Regulatory ... - Science
Within the eukaryotic nucleus, each gene is embedded within a chromosomal environment of other DNA sequences that have the potential to affect its expression.
#44. The Insulator Protein CTCF Is Required for Correct Hox Gene ...
ABSTRACT Insulator binding proteins (IBPs) play an important role in regulating gene expression by binding to specific DNA sites to.
#45. The role of insulator elements in defining domains of gene ...
Insulators are naturally occurring DNA sequences that protect transgenes from genomic position effects, thereby establishing independent functional domains ...
#46. Insulator Helps Silence Genes in Dormant Herpes Virus
Not simply passive barriers, insulators help organize and regulate gene activity by marking boundaries on chromatin, the condensed genetic ...
#47. Gene Mele: Topological insulators: mind the gap! | TED Talk
#48. Insulator (genetics) - Wikiwand
Insulators have two main functions: Enhancer-blocking insulators prevent distal enhancers from acting on the promoter of neighbouring genes; Barrier insulators ...
#49. Team:Calgary/Chromatin Modifying Elements - iGEM 2018
The mechanisms of insulator function have been previously described in ... Prospects and implications of using chromatin insulators in gene therapy and ...
#50. Insulator region - Altmeyers Encyclopedia
In the genetics of eukaryotes, the insulator region or isolator region of a ... Insulators can influence genes that are already "imprinted".
#51. Category:Insulator (genetics) - Wikimedia Commons
Media in category "Insulator (genetics)" · Gene enhancer.svg 400 × 122; 3 KB · File:Insulators-Target-Active-Genes-to-Transcription-Factories- ...
#52. Insulator Sequences and Application - Advanced ...
Insulators are DNA sequences that have the ability to protect genes from unintended signals. These sequences "insulate" genes from surrounding transcription ...
#53. [PDF] Chromatin Insulators and CTCF: Architects of Epigenetic ...
A controlled and efficient coordination of gene expression is the key for normal development of an organism. In mammals, a subset of autosomal genes is ...
#54. Solved 4. What would be the effect (on transcription) of - Chegg
Transcribed image text: 4. What would be the effect (on transcription) of moving the insulator below to a position between enhancer II and gene B's promoter ...
#55. Transcriptional regulation of gene expression in C. elegans
... organization and can block enhancer-stimulated gene expression, thus functioning as an insulator as shown in Figure 2 (Wallace and Felsenfeld, 2007).
#56. Lewin's Genes XI - 第 256 頁 - Google 圖書結果
The scs and scs' elements, like many other insulators, do not themselves play positive or negative roles in controlling gene expression, but restrict ...
#57. Scientists ID 10 NEFL Gene Mutations, May Help in CMT ...
Mutations in the NEFL gene, including three newly reported ones, may lead ... the insulating layer of nerve fibers — features called CMTDIG.
#58. Advanced Textbook On Gene Transfer, Gene Therapy And Genetic ...
Chromatin insulator DNA elements were discovered on the basis of their ability to confine regulatory sequences and to protect genes against extragenic ...
#59. Insulator (genetics) - Academic Dictionaries and Encyclopedias
An insulator is a genetic boundary element that plays two distinct roles in gene expression, either as an enhancer blocking element, or more…
#60. Isolador (genética) (Insulator (genetics)) 2021 - Artigos.wiki
A necessidade de isoladores surge quando dois genes adjacentes em um ... The genetic implications of insulators lie in their involvement in ...
#61. s41467_021_26155_5.pdf - DTU Orbit
A standardized genome architecture for bacterial synthetic biology (SEGA) ... and vice versa, insulating terminators flanking the landing pad.
#62. Regulation of gene expression - SlideShare
Insulator Elements (boundary elements) help to coordinate the regulation: 71. Gene regulatory proteins can affect transcription process at different steps ...
#63. Long-Range Control of Gene Expression - 第 211 頁 - Google 圖書結果
Furthermore, the contacts between Igf2 promoters and enhancers are prevented on the maternal allele when an active insulator is present.
#64. Action at a Distance Bacterial and eukaryotic enhancers ...
If a gene were placed upstream of such an insulator, it would always be silenced Experiments in Drosophila show that such genes can still be active and can be ...
#65. Capital Gains Tax allowances - GOV.UK
What Capital Gains Tax (CGT) is, how to work it out, current CGT rates and how to pay.
#66. Asian giants announced new chip wafer factories • The Register
... 200mm and 300mm Silicon on Insulator wafers (SOI), ... Freedom Bill promises already-slated GDPR reform, easier gene editing rules ...
#67. Gamma Probe Sales Market Overview, High Growth ...
Silicon On Insulator (Soi) In-Depth Sales Market Size, Development Data, Growth Analysis ... Dian Diagnostics, Daan Gene, Adicon Clinical, BGI Group, etc.
#68. Today in History - ABC News
... at a northern Illinois nuclear plant shut down after an electrical insulator failed. ... Today's Birthdays: Actor Gene Hackman is 92.
#69. OZ BIOSCIENCES (@OZBIOSCIENCES) / Twitter
[RESEARCH PAPER]: Controlling gene activation by enhancers through a drug-inducible topological insulator https://biorxiv.org/content/10.1101/534073v1.full…
#70. The quantum 'boomerang' effect has been seen for the first time
... electrons prevent the material from conducting electricity, thereby turning what might otherwise be a metal into an insulator.
#71. Fisher Scientific: Lab Equipment and Lab Supplies
Gene Editing and Gene Synthesis Tools. Invitrogen™ GeneArt™ Gene Synthesis and Strings™ DNA Fragments Tool. Chemical Structure.
#72. I'm Rooting for Everybody Black: Black Solidarity, Black World ...
... demand for Black freedom (at long last), or according to Gene Demby, ... involved plotlines or in other ways— by insulating readers from ...
#73. Loss-of-function variant - NEJM Illustrated Glossary
Cancer genome. Cancer genome ... Clinical genome and exome sequencing (CGES). Clinical genome and exome ... Epigenetic insulator. Epigenetic insulator ...
#74. The brain's secret to life-long learning can now come as ...
Engineers' New Topological Insulator Reroutes Photonic 'Traffic' on the Fly ... Will Knight, Genetic Literacy Project, 2018.
#75. G2: Business Software and Services Reviews
Compare the best business software and services based on user ratings and social data. Reviews for CRM, ERP, HR, CAD, PDM and Marketing software.
#76. IDAHO GLOBAL ENTREPRENEURIAL MISSION
Hempcrete is an insulating build- ... The genome research will provide better tools and data ... number of relevant genetic disease traits to increase.
#77. Coronavirus, how do vaccines work and when will they be ...
... have specialized, insulating RNA, the ribonucleic acid of a viral protein. ... “Because it is a very safe approach: the gene is DNA, ...
#78. How Epstein-Barr Virus Triggers Multiple Sclerosis
“Part of the EBV protein mimics your own host protein—in this case, GlialCAM, found in the insulating sheath on nerves,” said William ...
#79. Scientists identify 10 NEFL gene mutations that may help ...
Mutations in neurofilament light chain polypeptide (NEFL) Genes are a ... the insulating layer around nerve fibers—traits known as CMTDIG.
#80. Case Report: WPW and HCM Phenotype - CardioNerds
It is caused by mutations in the PRKAG2 gene, which encodes a portion ... so overcomes the insulating properties of the AV annulus fibrosus, ...
#81. Archives by Date - Nature India
Model shows when an insulator becomes a conductor ... Gene variation linked to less severe COVID-19 among South Asian ... Aloe vera genome decoded.
#82. On route to 3D printing with atomic resolution (w/video)
Nanotechnology strategies for plant genetic engineering ... New strategy achieves electric insulator polyethylene with high thermal ...
#83. Insulate Britain 'just getting started' with 'even more ambitious ...
“We are not heroes, we are not clairvoyants; Insulating Britain's cold and leaky homes is the first no-brainer step in reducing our energy ...
#84. Epigenetic Regulation and Epigenomics
Enhancer-blocking insulators can block the communication between an enhancer and a promoter, thereby inhibiting the enhancer from activating the gene.
#85. New optical device could help detect drugs, bomb-making ...
The sensor consists of two layers of metal with an insulator ... Gene important in soybean protein content found after 30-year search.
#86. Sulfur hexafluoride, SF 6 , is a very stable, nonflammable gas ...
It is used in many electronic products because it is a good electrical insulator. Which statement describes the composition of sulfur hexafluoride?? >>
#87. Topgo github - meleyin.biz
topGO: Enrichment Analysis for Gene Ontology. ... system functions as a drug-inducible topological insulator to control gene activation by enhancers.
#88. Chromatin Structure and Gene Expression - 第 299 頁 - Google 圖書結果
Gerasimova , T. I. and Corces , V.G. ( 1998 ) Polycomb and trithorax group proteins mediate the function of a chromatin insulator . Cell , 92,511 . 68.
#89. Best cashmere turtleneck - WATE
4 天前 — Regular turtlenecks are worn as layering pieces underneath a different garment and can be fairly lightweight and less insulating.
#90. Two-dimensional material could store quantum information at ...
“Usually, it's a pretty boring material that's normally used as an insulator,” said Stern, who is a Junior Research Fellow at Trinity ...
#91. Building Supervisor (Clay Center, NE) - LinkedIn
... assists with new construction as needed, includes: electrical, plumbing, masonry, concrete, flooring, insulating pipes and walls, etc.
#92. Ask Away: Cold-weather workouts | Pittsburgh Post-Gazette
Several layers of light clothing are preferable to one or two bulky coats, and can provide an insulating cushion of air that helps to retain ...
#93. INSULIGN® Polymer Insulator - Tie Top | PLP - Preformed ...
INSULIGN ® Tie Top Polymer Insulators are designed to match the head, ... 55-6, and 55-7 as well as ANSI C29.6, Class 56-1 pin-type insulator standards.
#94. Global Ceramic Fiber Market 2021 Industry Outlook and Sales ...
... Morgan Thermal Ceramics, Shandong Luyang Share, Isolite Insulating Products ... Nutec Fibratec, Rath, Unifrax I LLC, Yeso Insulating Products Co.
insulator gene 在 Topgo github - meleyin.biz 的推薦與評價
topGO: Enrichment Analysis for Gene Ontology. ... system functions as a drug-inducible topological insulator to control gene activation by enhancers. ... <看更多>