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#1. Cholecystokinin B receptor - Wikipedia
The cholecystokinin B receptor also known as CCKBR or CCK2 is a protein that in humans is encoded by the CCKBR gene.
#2. Cholecystokinin B Receptor - an overview - ScienceDirect.com
The CCK2 receptor belongs to the family of G protein-coupled receptors, characterized by seven transmembrane domains. It acts via the Gαq/11 group of G proteins ...
#3. Cholecystokinin-2 (CCK2) receptor-mediated ... - PubMed
Cholecystokinin (CCK) is a neurotransmitter in the brain closely related to anxiety. Of the two CCK receptor subtypes, CCK(2) receptors are most implicated ...
#4. Gastrin, Cholecystokinin, Signaling, and Biological Activities in ...
Gastrin receptor is also referred as CCK2 receptor (CCK2R, previously also called CCK-B receptor) based on the facts that (1) gastrin and ...
#5. CCK 2 receptor - IUPHAR/BPS Guide to PHARMACOLOGY
Ligand Sp. Action Value PBC‑264 Rn Full agonist 9.7 ⤷ pKd 9.7 (Kd 2x10 ‑10 M) pKd 9.7 (Kd 2x10 ‑10 M) pKd 9.7 (Kd 2x10 ‑10 M) pKd 9.7... RB‑400 Rn Full agonist 9.1
#6. Cholecystokinin CCK2 receptor assay - Innoprot
This gene encodes a G-protein-coupled receptor for gastrin and cholecystokinin, regulatory peptides of the brain and gastrointestinal tract. Therefore, It is ...
#7. Cell-Type-Specific CCK2 Receptor Signaling Underlies ...
CCK2 receptors are classically thought to be linked to the Gq/11-protein–phospholipase C (PLC) pathway, largely based on studies using ...
#8. CCK2 receptor antagonists - Taylor & Francis Online
Recognition that the gastrointestinal polypeptide hormone gastrin affects diverse actions, such as gastric acid secretion and gastrointestinal cell growth ...
#9. Characterization of gastrin–cholecystokinin 2 receptor ...
Gastrin-17 dose dependently increased c-fos induction in both cancer cell lines. L365,260, a known CCK2 receptor antagonist, completely blocked ...
#10. Radiolabeled CCK/gastrin peptides for imaging and therapy of ...
The CCK2 receptor therefore is also referred to as gastrin receptor. The third type of CCK receptors is the CCK2i4sv receptor, a splice variant ...
#11. CCK2 (non-phospho), Cholecystokinin Receptor 2 Antibody
The CCK2 antibody can also be used to isolate and enrich CCK2 receptors from cell and tissue lysates.
#12. CCK 2 Receptors - Tocris Bioscience
The cholecystokinin2 receptor (CCK2 receptor, CCK-B receptor) is a member of the cholecystokinin receptor group of G-protein-coupled receptors that also ...
#13. Anti-CCKBR (CCKB, Cholecystokinin-2 Receptor, CCK-BR ...
Buy Anti-CCKBR (CCKB, Cholecystokinin-2 Receptor, CCK-BR, CCK2 Receptor, CCK2-R, CCKB-R, Cholecystokinin, item number: 170243.50 from United States ...
#14. Ready-to-Assay™ CCK2 Cholecystokinin Receptor Frozen ...
Ready-to-Assay™ CCK2 Cholecystokinin Receptor Frozen Cells. Cholecystokinins are a series of peptides of heterogeneous length (5 to 58 amino acids) that are ...
#15. CCK2 Receptors - GPCR/G protein - Signaling Pathways
CCK2 Receptors. 7 Items. Show. 5, 10, 15, 20, 25. per page. LY 288513. B5125 LY 288513. Summary: Selective CCK2 receptor antagonist. <43.63 mg/mL.
#16. Behavioral Profile of CCK2 Receptor-deficient Mice - Nature
CCK2 receptor -deficient mice were used to investigate in vivo the role of this receptor in behavior. Mutant mice showed a neuromuscular ...
#17. CCK2 Receptor Antagonists Products | Bio-Techne
View 5 CCK2 Receptor Antagonists products. Bio-Techne offers high-quality reagents, instruments, custom manufacturing and testing services.
#18. CCKBR Gene - GeneCards | GASR Protein | GASR Antibody
The cholecystokinin2 receptor (CCK2 receptor, CCK-B receptor) is a member of the cholecystokinin receptor group of G-protein-coupled receptors that also ...
#19. Identification of a series of CCK-2 receptor nonpeptide agonists
The search for small-molecule drugs that act at peptide hormone receptors has ... The cholecystokinin (CCK) 2 receptor (CCK-2R, previously known as the ...
#20. CCK2 Receptor Agonists Products - R&D Systems
View our 2 CCK2 Receptor Agonists Peptides for your research.
#21. CCKBR - Gastrin/cholecystokinin type B receptor | UniProtKB
Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, ...
#22. CCK2 gastrin receptor as a potential target for therapy in ...
We tested four leukaemia cell lines, KU812, ML-1, MOLT-4 and U937 for the existence of the CCK2 receptor and gastrin precursor protein using ...
#23. Structural studies on radiopharmaceutical DOTA-minigastrin ...
Structural studies on radiopharmaceutical DOTA-minigastrin analogue (CP04) complexes and their interaction with CCK2 receptor.
#24. LY 225910, CCK2 receptor antagonist (ab141320) - Abcam
MW 502.41, Purity > 99%. Potent, selective CCK2 receptor antagonist (IC50 = 9.3 nM). Shows anxiolytic effects in vivo.
#25. CCK2-CCKB-Human-Cholecystokinin-GPCR-Cell-Based ...
G-protein-coupled receptors constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions ...
#26. CCK2 receptor antagonists - ResearchGate
Download Citation | CCK2 receptor antagonists | Recognition that the gastrointestinal polypeptide hormone gastrin affects diverse actions, such as gastric ...
#27. CCK2 receptor nullification attenuates lipopolysaccharide ...
Although several studies have examined the role of the CCK1 receptor in sickness behavior, relatively little attention has been paid to CCK2 receptors. Blockade ...
#28. Ready-to-Assay™ CCK2 Cholecystokinin Receptor Frozen Cells
Ready-to-Assay™ CCK2 Cholecystokinin Receptor Frozen Cells Human CCK2 / CCKb GPCR frozen cells for Calcium Flux FLIPR Assays. - Find MSDS or SDS, a COA, ...
#29. Randomized Controlled Trial of the Gastrin/CCK2 Receptor ...
The gastrin/CCK2 receptor antagonist netazepide did not reduce cellular proliferation in patients with nondysplastic Barrett's esophagus. Further research ...
#30. CCK1 and CCK2 Receptors Are Expressed on Pancreatic ...
Using specific CCK1 and CCK2 receptor (CCK2R) inhibitors, we found that Akt activation is mainly mediated by CCK2R. Akt activation by CCK and ...
#31. Protecting-group-free synthesis of a dual CCK1/CCK2 ...
In our pursuit of an efficient, protecting-group-free synthesis of the dual CCK1/CCK2 receptor antagonist 1, we have developed chemoselective conditions for ...
#32. Further evidence that the CCK2 receptor is ... - HAL-Inserm
Activation of wild-type as well as F347A, D100N or K333M/K334T/R335L CCK2 receptors by this ligand led to a similar arachidonic acid release which was blocked ...
#33. Cckbr - cholecystokinin B receptor - WikiGenes
Deletion of the CCK2 receptor gene reduces mechanical sensitivity and abolishes the development of hyperalgesia in mononeuropathic mice [2].
#34. Distinct CCK-2 Receptor Conformations Associated with β ...
Distinct CCK-2 Receptor Conformations Associated with β-Arrestin-2 Recruitment or Phospholipase-C Activation Revealed by a Biased Antagonist.
#35. Cholecystokinin Receptor | Antagonists Agonists
Gastrin I, human is the endogenous peptide produced in the stomach, and increases gastric acid secretion via cholecystokinin 2 (CCK2) receptor.
#36. Cholecystokinin-2 (CCK2) receptor ... - ScholarBank@NUS
Cholecystokinin-2 (CCK2) receptor-mediated anxiety-like behaviors in rats. Neuroscience and Biobehavioral Reviews 29 (8) : 1361-1373.
#37. Mechanism for Src activation by the CCK2 receptor
AIM: To investigate in vivo, whether CCK2 receptors (CCK2R) regulate proteins known to play a crucial role in cell proliferation and cancer development and ...
#38. Involvement of Cholecystokinin 2 Receptor in Food Intake ...
Although most work implies that CCK1 receptor mediates the control of food intake, a contributing role for CCK2 receptor (CCK2R) in the CCK-induced satiety ...
#39. Distribution of CCK1 and CCK2 receptors in normal and ...
Results: CCK2 receptor mRNA and proteins were found abundantly in human pancreatic islets in normal pancreas and chronic pancreatitis. CCK1 receptor proteins ...
#40. human Cholecystokinin CCK2 Receptor - PerkinElmer
Bmax and Kd are determined using radioactive saturation binding assays (Figure 1). Protein concentration is determined using the BCA method (1).
#41. A New Interest Towards the Development of CCK2 Agonists
Although CCK2 receptors have been proved to be structurally homogeneous, ... the pharmacological profiles linked to CCK2 receptor activation is not yet ...
#42. Cell-type dependent selectivity of CCK2R signaling (WP3679)
This pathway is based on Figure 7 of "Cell-Type Specific CCK2 Receptor Signaling Underlies the Cholecystokinin-Mediated Selective Excitation of Hippocampal ...
#43. QSAR Modeling of CCK2 Receptor Antagonists Utilizing ...
The CCK2 receptor is expressed in the brain and the gastric fundus (Innis and Snyder, 1980). CCK occupies the CCK2 receptor present in the brain and mediates ...
#44. Permanent Photodynamic Activation of the Cholecystokinin 2 ...
The cholecystokinin 2 receptor (CCK2R) is expressed in the central nervous system and peripheral tissues, playing an important role in higher nervous and ...
#45. The cholecystokinin receptor family : molecular cloning and ...
Three 5'-end alternatively spliced human CCK2 receptor mRNAs were cloned: the CCK-BRwt mRNA, that encodes the ordinary full-length CCK2 ...
#46. PET and SPECT imaging with a CCK2 receptor-binding ...
Objectives Radiolabeled gastrin analogs can be used for imaging and therapy of tumors expressing CCK2/gastrin receptors (CCK2R).
#47. ChemiScreen Recombinant Human CCK2 Cholecystokinin ...
ChemiScreen Recombinant Human CCK2 Cholecystokinin Receptor Membrane Preparation Human CCK2 / CCKb GPCR membrane preparation for Radioligand binding Assays ...
#48. ChemiScreen™ Recombinant Human CCK2 Cholecystokinin ...
HTS083M Sigma-AldrichChemiScreen™ Recombinant Human CCK2 Cholecystokinin Receptor Membrane Preparation · Human CCK2 / CCKb GPCR membrane preparation for ...
#49. Human tissues expressing gastrin and the gastrin receptor ...
Share. © 2023 UpToDate, Inc. and/or its affiliates. All Rights Reserved. Human tissues expressing gastrin and the gastrin receptor CCK2 ...
#50. Expression of multiple forms of 3'-end variant CCK2 receptor ...
However, it has been suggested that CCK1- and CCK2-receptors are differently expressed in normal human pancreas and pancreatic cancer cells ...
#51. A phase Ib/IIa trial to evaluate the CCK2 receptor antagonist Z ...
Novel treatments with a CCK2 receptor antagonist could suppress both acid secretion and the growth-promoting ef- fects of gastrin.
#52. CHO-K1/CCKB Stable Cell Line - GenScript
There are two cholecystokinin receptors, referred to as A and B (CCKAR and ... CCK2 receptor, CCK-B, CCK-B/gastrin, CCKB/gastrin, CCKB, CHOLREC, Cck2r, ...
#53. CCK2 receptor splice variant with intron 4 retention in human ...
The wild-type cholecystokinin type 2 (CCK2) receptor is expressed in many gastrointestinal and lung tumours. A splice variant of the.
#54. Aryl sulfonamide compounds as modulators of the cck2 receptor
Certain aryl sulfonamide compounds are CCK2 receptor modulators useful in the treatment of CCK2 receptor-mediated diseases.
#55. Further evidence that the CCK2 receptor is coupled to two ...
Activation of wild-type as well as F347A, D100N or K333M/K334T/R335L CCK2 receptors by this ligand led to a similar arachidonic acid release ...
#56. Eurofins Discoverx Ready-to-Assay CCK2 Cholecystokinin ...
Shop Eurofins Discoverx Ready-to-Assay CCK2 Cholecystokinin Receptor Frozen Cells, 2 Vials of Cells. (HTS083RTA) at Fishersci.com.
#57. Genetic Variations in CCK2 Receptor in PVG Hooded and ...
The authors confirmed by reverse transcription polymerase chain reaction that CCK2 receptor expression in the PVG rats was increased in the hippocampus and ...
#58. Pharmacological analysis of CCK2 receptor ligands using ...
A series of CCK2 receptor ligands were analysed with respect to their interaction with binding sites in the membranes of COS-7 cells and SK-N-MC cells ...
#59. mini-gastrin analogue, in particular for use in cck2 receptor ...
It is the objective of the present invention to provide a gastrin analogue which show high uptake in CCK-2 receptor positive tumours by ...
#60. OC-097 The novel gastrin/CCK2 receptor antagonist YF476 ...
OC-097 The novel gastrin/CCK2 receptor antagonist YF476 induces clinical responses and is well tolerated in patients with type I gastric neuroendocrine ...
#61. Acquisition of analgesic properties by the cholecystokinin ...
... analgesic properties by the cholecystokinin (CCK)/CCK2 receptor system within the amygdala in a persistent inflammatory pain condition.
#62. Comparative biodistribution of 12 ¹¹¹In-labelled gastrin/CCK2 ...
PURPOSE: Cholecystokinin 2 (CCK-2) receptor overexpression has been demonstrated in various tumours such as medullary thyroid carcinomas and ...
#63. CCK2 Receptors - GPCR/G protein - BioCrick
The cholecystokinin B receptor also known as CCKBR or CCK2 is a protein[4] that in humans is encoded by the CCKBR gene.
#64. Functional changes of dopamine, endopioid and ... - DSpace
... endopioid and endocannabinoid systems in CCK2 receptor deficient ... 2) kuidas CCK2 retseptorite (CCK2R) geneetiline väljalülitamine ...
#65. CCK-1 and CCK-2 receptor agonism do not stimulate GLP-1 ...
CCK-1 and CCK-2 receptor agonism do not stimulate GLP-1 and neurotensin secretion in the isolated perfused rat small intestine or GLP-1 and PYY secretion in ...
#66. CCKBR (CCKBR, CCKB, Cholecystokinin-2 Receptor, CCK ...
A Data Sheet for CCKBR (CCKBR, CCKB, Cholecystokinin-2 Receptor, CCK-BR, CCK2 Receptor, CCK2-R, CCKB-R, Cholecystokinin-B, GASR, CCK-B, CCK-B Receptor, ...
#67. Potential clinical indications for a CCK2 receptor antagonist
Gastrin controls gastric acid secretion and mucosal cell growth, especially of enterochromaffin-like cells, via gastrin/cholecystokinin-2 receptor (CCK2R) ...
#68. CCK2 receptor expression transforms non-tumorigenic human ...
To determine the effects of ectopic CCK2 receptor variant expression on colonic epithelial cell growth in vitro and in vivo, we employed the non ...
#69. Achiral, selective CCK2 receptor antagonists based on a 1,3,5 ...
These compounds are potent CCK2 receptor antagonists that display a high degree of selectivity over CCK1 receptors. Item Type: Article.
#70. CCK2 (CCKB/gastrin) receptor mediates rapid protein kinase ...
CCK2 (CCKB/gastrin) receptor induced protein kinase D (PKD) activation that was detectable within 1 min and reached a maximum (V10-fold) after 2.5 min of ...
#71. Cholecystokinin-2 Receptor | Encyclopedia MDPI
Comparison of three radiolabelled peptide analogues for CCK-2 receptor scintigraphy in medullary thyroid carcinoma. Eur. J. Nucl. Med. Mol. Imaging 2009, 36, ...
#72. CCK2 receptors are necessary for the differentiation and ...
In CCK2 receptor knockout mice, the ECL cells were replaced by a novel endocrine-like cell type lacking histamine and histidine ...
#73. Handbook of Biologically Active Peptides - 第 285 頁 - Google 圖書結果
CCK-8 and caerulein bind to CCK receptors [45]. There are two types of CCK receptor: CCK1 and CCK2— differing in anatomical locations and actions [15].
#74. Relation Results - SIGNOR 3.0
Synonyms, CCK-B receptor, CCK-BR, Cholecystokinin-2 receptor, CCK2-R | CCKRB ... The CCK-B receptors occur throughout the central nervous system where they ...
#75. Critical Pathways to Success in CNS Drug Development
(1994) Opposite effects mediated by CCKA and CCKB receptors in behavioural and ... (2007) Strategies for the design of non-peptide CCK2 receptor agonist and ...
#76. International Union of Pharmacology. XXI. Structure ...
CCK receptor agonists, endogenous or exogenous, stimulate CCK2 and/or CCK1 receptors, which can modulate the opioidergic (enkephalinergic) ...
#77. CCK2-Rezeptor - DocCheck Flexikon
CCK2 -Rezeptoren, kurz CCK2, sind ein Subtyp der CCK-Rezeptoren, der in Gehirn, Magen und Pankreas vorkommt. ... Englisch: cholecystokinin B receptor ...
#78. Cumulated Index Medicus
Zhang L , et al . neurotensin , somatostatin and vasoactive intestinal peptide Discovery of new CCK2 receptor antagonists . A review of F. Methods Find Exp ...
#79. The Role of Gastrin and CCK Receptors in Pancreatic Cancer ...
Gastrin increases its own synthesis in gastrointestinal cancer cells via the CCK2 receptor. FEBS Lett. 2010;584:4413-4418.
#80. Frontiers in CNS Drug Discovery - 第 1 卷 - 第 203 頁 - Google 圖書結果
Cholecystokinin-2 (CCK2) receptor-mediated anxiety-like behaviors in rats. Neurosci Biobehav Rev 2005; 29: 1361-1373. Ise K, Akiyoshi J, Horinouchi Y, ...
#81. Neuropeptides in Neuroprotection and Neuroregeneration
These hormones probably act by activating β-noradrenergic receptor systems in the ... Furthermore, a CCK(2) receptor agonist (Boc-CCK-4) improved water-maze ...
#82. Novel Pain Therapeutics: From Basic Research to Clinical ...
Deletion of the CCK2 receptor gene reduces mechanical sensitivity and abolishes the development of hyperalgesia in mononeuropathic mice. Eur. J. Neurosci.
#83. Targeting Neuroinflammation in Central Nervous System ...
P2X3 receptors and peripheral pain mechanisms. ... Acquisition of analgesic properties by the cholecystokinin (CCK)/CCK2 receptor system within the amygdala ...
#84. Index Medicus - 第 45 卷，第 1 期，第 1 篇 - 第 228 頁 - Google 圖書結果
Be BEETS see BETA VULGARIS The adenosine receptor antagonist CGS15943 reinstates ... stress reinstates alcohol - seeking in CCK2 receptor - deficient mice .
#85. Cholecystokinin Type 1 Receptor - Pancreapedia
Strategies for the design of non-peptide CCK2 receptor agonist and antagonist ligand. Curr Top Med Chem 7:1195-1204, 2007.
#86. Comments - YouTube
GASTRIN, CCK AND CANCER! Gastrin, CCK, and Secretin functions in health and disease explained! · Comments.
cck2 receptor 在 Comments - YouTube 的推薦與評價
GASTRIN, CCK AND CANCER! Gastrin, CCK, and Secretin functions in health and disease explained! · Comments. ... <看更多>